STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisC2Histidinol-phosphate aminotransferase 2; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (361 aa)    
Predicted Functional Partners:
hisB
Imidazoleglycerol-phosphate dehydratase; Identified by sequence similarity.
 
 0.998
tyrA
Prephenate dehydrogenase; Identified by sequence similarity.
 
 
 0.974
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.951
hisC1
Histidinol-phosphate aminotransferase 1; Identified by sequence similarity; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
  
 
0.911
pheA
Prephenate dehydratase; Identified by sequence similarity.
  
 
 0.907
Lxx13400
Inositol monophosphatase; Identified by sequence similarity.
  
 
 0.906
hisF
Imidazoleglycerol-phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.854
hisH
Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.840
pdhA
Pyruvate dehydrogenase E1 component, alpha subunit; Identified by sequence similarity.
       0.833
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
  
 0.816
Your Current Organism:
Leifsonia xyli CTCB07
NCBI taxonomy Id: 281090
Other names: L. xyli subsp. xyli str. CTCB07, Leifsonia xyli subsp. xyli CTCB07, Leifsonia xyli subsp. xyli str. CTCB07, Leifsonia xyli subsp. xyli strain CTCB07
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.