STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (384 aa)    
Predicted Functional Partners:
pta
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
 
 
 0.999
acs
acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
   
 
 0.993
KU46_1664
Aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family.
 
 
 0.991
KU46_648
Aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family.
 
 
 0.875
KU46_167
Zinc-binding dehydrogenase family protein.
  
 
 0.565
KU46_75
enoyl-CoA hydratase/isomerase family protein.
    
 0.533
KU46_76
acCoA-C-Actrans: acetyl-CoA C-acyltransferase family protein; Belongs to the thiolase-like superfamily. Thiolase family.
    
 0.529
ssb
Single-stranded DNA-binding family protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
       0.524
sucC
succinate-CoA ligase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
     
 0.520
KU46_74
Hypothetical protein; acyl-CoA dehydrogenase, N-terminal domain protein.
     
 0.520
Your Current Organism:
Francisella philomiragia
NCBI taxonomy Id: 28110
Other names: ATCC 25015, CCUG 19700, CCUG 4992, CIP 82.98, DSM 7535, F. philomiragia, Francisella philomiragia subsp. philomiragia, Yersinia philomiragia, strain O#319L
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.