node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KU46_1501 | folC | KU46_1501 | KU46_808 | folB_dom: FolB domain protein. | folC: bifunctional FolC family protein. | 0.688 |
KU46_1501 | folK | KU46_1501 | KU46_1500 | folB_dom: FolB domain protein. | folK: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | 0.999 |
KU46_809 | accD | KU46_809 | KU46_807 | T6A_YjeE: tRNA threonylcarbamoyl adenosine modification protein YjeE. | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | 0.759 |
KU46_809 | folC | KU46_809 | KU46_808 | T6A_YjeE: tRNA threonylcarbamoyl adenosine modification protein YjeE. | folC: bifunctional FolC family protein. | 0.849 |
KU46_809 | ndk | KU46_809 | KU46_806 | T6A_YjeE: tRNA threonylcarbamoyl adenosine modification protein YjeE. | Nucleoside diphosphate kinase family protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.645 |
KU46_809 | pyrG | KU46_809 | KU46_805 | T6A_YjeE: tRNA threonylcarbamoyl adenosine modification protein YjeE. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.458 |
accD | KU46_809 | KU46_807 | KU46_809 | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | T6A_YjeE: tRNA threonylcarbamoyl adenosine modification protein YjeE. | 0.759 |
accD | folC | KU46_807 | KU46_808 | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | folC: bifunctional FolC family protein. | 0.900 |
accD | ndk | KU46_807 | KU46_806 | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | Nucleoside diphosphate kinase family protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.642 |
accD | pyrG | KU46_807 | KU46_805 | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.489 |
dfrA | folC | KU46_753 | KU46_808 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | folC: bifunctional FolC family protein. | 0.996 |
dfrA | folK | KU46_753 | KU46_1500 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | folK: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | 0.561 |
dfrA | glyA | KU46_753 | KU46_1884 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Beta-eliminating lyase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.992 |
dfrA | thyA | KU46_753 | KU46_1876 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
folC | KU46_1501 | KU46_808 | KU46_1501 | folC: bifunctional FolC family protein. | folB_dom: FolB domain protein. | 0.688 |
folC | KU46_809 | KU46_808 | KU46_809 | folC: bifunctional FolC family protein. | T6A_YjeE: tRNA threonylcarbamoyl adenosine modification protein YjeE. | 0.849 |
folC | accD | KU46_808 | KU46_807 | folC: bifunctional FolC family protein. | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | 0.900 |
folC | dfrA | KU46_808 | KU46_753 | folC: bifunctional FolC family protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.996 |
folC | folK | KU46_808 | KU46_1500 | folC: bifunctional FolC family protein. | folK: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | 0.998 |
folC | glyA | KU46_808 | KU46_1884 | folC: bifunctional FolC family protein. | Beta-eliminating lyase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.694 |