ALJ46897.1 protein (Bacteroides ovatus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ALJ46897.1

Hypothetical protein. (110 aa)

Predicted Functional Partners:

inlJ

0.953

ALJ46895.1

0.620

ALJ46898.1

0.548

znuB

0.548

tsaE

0.527

ALJ46901.1

0.527

ALJ46902.1

0.401

ALJ46903.1

0.401

Your Current Organism:

Bacteroides ovatus

NCBI taxonomy Id: 28116
Other names: ATCC 8483, B. ovatus, BCRC 10623, Bacteroides fragilis subsp. ovatus, CCRC 10623, CCRC:10623, CCUG 4943, CIP 103756, JCM 5824, NCTC 11153, Pasteurella ovata, Pseudobacterium ovatum, bacterium NLAE-zl-C11, bacterium NLAE-zl-C34, bacterium NLAE-zl-C500, bacterium NLAE-zl-C57, bacterium NLAE-zl-H304, bacterium NLAE-zl-H361, bacterium NLAE-zl-H59, bacterium NLAE-zl-H73

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALJ46895.1	ALJ46897.1	Bovatus_02262	Bovatus_02264	Aminopeptidase S.	Hypothetical protein.	0.620
ALJ46895.1	ALJ46898.1	Bovatus_02262	Bovatus_02265	Aminopeptidase S.	Hypothetical protein.	0.502
ALJ46895.1	ALJ46901.1	Bovatus_02262	Bovatus_02268	Aminopeptidase S.	Hypothetical protein.	0.453
ALJ46895.1	inlJ	Bovatus_02262	Bovatus_02263	Aminopeptidase S.	Internalin-J precursor.	0.661
ALJ46895.1	tsaE	Bovatus_02262	Bovatus_02267	Aminopeptidase S.	tRNA threonylcarbamoyladenosine biosynthesis protein TsaE.	0.453
ALJ46895.1	znuB	Bovatus_02262	Bovatus_02266	Aminopeptidase S.	High-affinity zinc uptake system membrane protein ZnuB.	0.469
ALJ46897.1	ALJ46895.1	Bovatus_02264	Bovatus_02262	Hypothetical protein.	Aminopeptidase S.	0.620
ALJ46897.1	ALJ46898.1	Bovatus_02264	Bovatus_02265	Hypothetical protein.	Hypothetical protein.	0.548
ALJ46897.1	ALJ46901.1	Bovatus_02264	Bovatus_02268	Hypothetical protein.	Hypothetical protein.	0.527
ALJ46897.1	ALJ46902.1	Bovatus_02264	Bovatus_02269	Hypothetical protein.	Nucleotidyltransferase domain protein.	0.401
ALJ46897.1	ALJ46903.1	Bovatus_02264	Bovatus_02270	Hypothetical protein.	Hypothetical protein.	0.401
ALJ46897.1	inlJ	Bovatus_02264	Bovatus_02263	Hypothetical protein.	Internalin-J precursor.	0.953
ALJ46897.1	tsaE	Bovatus_02264	Bovatus_02267	Hypothetical protein.	tRNA threonylcarbamoyladenosine biosynthesis protein TsaE.	0.527
ALJ46897.1	znuB	Bovatus_02264	Bovatus_02266	Hypothetical protein.	High-affinity zinc uptake system membrane protein ZnuB.	0.548
ALJ46898.1	ALJ46895.1	Bovatus_02265	Bovatus_02262	Hypothetical protein.	Aminopeptidase S.	0.502
ALJ46898.1	ALJ46897.1	Bovatus_02265	Bovatus_02264	Hypothetical protein.	Hypothetical protein.	0.548
ALJ46898.1	ALJ46901.1	Bovatus_02265	Bovatus_02268	Hypothetical protein.	Hypothetical protein.	0.760
ALJ46898.1	ALJ46902.1	Bovatus_02265	Bovatus_02269	Hypothetical protein.	Nucleotidyltransferase domain protein.	0.547
ALJ46898.1	ALJ46903.1	Bovatus_02265	Bovatus_02270	Hypothetical protein.	Hypothetical protein.	0.547
ALJ46898.1	inlJ	Bovatus_02265	Bovatus_02263	Hypothetical protein.	Internalin-J precursor.	0.518

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.841

expected number of edges:

35

PPI enrichment p-value:

0.988

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019842

Vitamin binding

5 of 54

1.57

1.64

0.00011

GO:0030976

Thiamine pyrophosphate binding

3 of 9

2.13

1.58

0.00090

GO:0016903

Oxidoreductase activity, acting on the aldehyde or oxo group of donors

3 of 24

1.7

1.13

0.0047

GO:0005506

Iron ion binding

3 of 52

1.36

0.76

0.0202

GO:0036094

Small molecule binding

8 of 644

0.7

0.52

0.0043

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1749

Pyruvate:ferredoxin oxidoreductase core domain II

3 of 5

2.38

1.72

0.00061

CL:1313

Histidine biosynthesis

2 of 5

2.2

0.89

0.0222

CL:4893

Mixed, incl. Peptidase M3A/M3B, and acyl-CoA hydrolase activity

2 of 6

2.13

0.86

0.0247

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00650

Butanoate metabolism

4 of 41

1.59

1.49

0.00036

map00020

Citrate cycle (TCA cycle)

3 of 23

1.72

1.31

0.0018

map00010

Glycolysis / Gluconeogenesis

3 of 39

1.49

1.04

0.0048

map00620

Pyruvate metabolism

3 of 55

1.34

0.89

0.0080

map00450

Selenocompound metabolism

2 of 29

1.44

0.65

0.0437

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0249

Electron transport

3 of 11

2.04

1.7

0.00045

KW-0670

Pyruvate

3 of 18

1.82

1.44

0.0011

KW-0479

Metal-binding

7 of 278

1.0

0.93

0.00025

KW-0368

Histidine biosynthesis

2 of 12

1.82

0.81

0.0273

KW-0028

Amino-acid biosynthesis

3 of 68

1.25

0.68

0.0273

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF17147

Pyruvate:ferredoxin oxidoreductase core domain II

3 of 5

2.38

1.8

0.00042

PF01855

Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg

3 of 6

2.3

1.79

0.00042

PF01558

Pyruvate ferredoxin/flavodoxin oxidoreductase

3 of 6

2.3

1.79

0.00042

PF02775

Thiamine pyrophosphate enzyme, C-terminal TPP binding domain

3 of 8

2.18

1.76

0.00042

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR037112

Pyruvate-flavodoxin oxidoreductase, EKR domain superfamily

3 of 3

2.6

1.85

0.00039

IPR019456

Pyruvate-flavodoxin oxidoreductase, EKR domain

3 of 3

2.6

1.85

0.00039

IPR011895

Pyruvate-flavodoxin oxidoreductase

3 of 3

2.6

1.85

0.00039

IPR033412

Pyruvate:ferredoxin oxidoreductase, core domain II

3 of 5

2.38

1.82

0.00039

IPR019752

Pyruvate/ketoisovalerate oxidoreductase, catalytic domain

3 of 6

2.3

1.8

0.00039

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00890

Domain of unknown function

3 of 3

2.6

2.4

3.42e-05

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