node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SJZ45442.1 | SJZ84567.1 | SAMN02745108_00617 | SAMN02745108_01754 | ATP-dependent Clp protease ATP-binding subunit ClpB; Belongs to the ClpA/ClpB family. | Thiol-disulfide isomerase or thioredoxin. | 0.438 |
SJZ45442.1 | SKA04555.1 | SAMN02745108_00617 | SAMN02745108_02328 | ATP-dependent Clp protease ATP-binding subunit ClpB; Belongs to the ClpA/ClpB family. | ATP-dependent Lon protease. | 0.761 |
SJZ45442.1 | clpP | SAMN02745108_00617 | SAMN02745108_02330 | ATP-dependent Clp protease ATP-binding subunit ClpB; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, protease subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.923 |
SJZ45442.1 | dnaJ | SAMN02745108_00617 | SAMN02745108_00610 | ATP-dependent Clp protease ATP-binding subunit ClpB; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.886 |
SJZ45442.1 | dnaK | SAMN02745108_00617 | SAMN02745108_00609 | ATP-dependent Clp protease ATP-binding subunit ClpB; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.988 |
SJZ45442.1 | groL | SAMN02745108_00617 | SAMN02745108_00607 | ATP-dependent Clp protease ATP-binding subunit ClpB; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.735 |
SJZ45442.1 | grpE | SAMN02745108_00617 | SAMN02745108_00608 | ATP-dependent Clp protease ATP-binding subunit ClpB; Belongs to the ClpA/ClpB family. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.900 |
SJZ45442.1 | htpG | SAMN02745108_00617 | SAMN02745108_00539 | ATP-dependent Clp protease ATP-binding subunit ClpB; Belongs to the ClpA/ClpB family. | Molecular chaperone HtpG; Molecular chaperone. Has ATPase activity. | 0.809 |
SJZ84567.1 | SJZ45442.1 | SAMN02745108_01754 | SAMN02745108_00617 | Thiol-disulfide isomerase or thioredoxin. | ATP-dependent Clp protease ATP-binding subunit ClpB; Belongs to the ClpA/ClpB family. | 0.438 |
SJZ84567.1 | SKA04555.1 | SAMN02745108_01754 | SAMN02745108_02328 | Thiol-disulfide isomerase or thioredoxin. | ATP-dependent Lon protease. | 0.856 |
SJZ84567.1 | dnaJ | SAMN02745108_01754 | SAMN02745108_00610 | Thiol-disulfide isomerase or thioredoxin. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.907 |
SJZ84567.1 | dnaK | SAMN02745108_01754 | SAMN02745108_00609 | Thiol-disulfide isomerase or thioredoxin. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.936 |
SJZ84567.1 | groL | SAMN02745108_01754 | SAMN02745108_00607 | Thiol-disulfide isomerase or thioredoxin. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.566 |
SJZ84567.1 | grpE | SAMN02745108_01754 | SAMN02745108_00608 | Thiol-disulfide isomerase or thioredoxin. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.491 |
SJZ84567.1 | htpG | SAMN02745108_01754 | SAMN02745108_00539 | Thiol-disulfide isomerase or thioredoxin. | Molecular chaperone HtpG; Molecular chaperone. Has ATPase activity. | 0.522 |
SKA04555.1 | SJZ45442.1 | SAMN02745108_02328 | SAMN02745108_00617 | ATP-dependent Lon protease. | ATP-dependent Clp protease ATP-binding subunit ClpB; Belongs to the ClpA/ClpB family. | 0.761 |
SKA04555.1 | SJZ84567.1 | SAMN02745108_02328 | SAMN02745108_01754 | ATP-dependent Lon protease. | Thiol-disulfide isomerase or thioredoxin. | 0.856 |
SKA04555.1 | clpP | SAMN02745108_02328 | SAMN02745108_02330 | ATP-dependent Lon protease. | ATP-dependent Clp protease, protease subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.898 |
SKA04555.1 | clpX | SAMN02745108_02328 | SAMN02745108_02329 | ATP-dependent Lon protease. | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.905 |
SKA04555.1 | dnaJ | SAMN02745108_02328 | SAMN02745108_00610 | ATP-dependent Lon protease. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.793 |