node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KXO18107.1 | KXO18111.1 | HMPREF3202_00447 | HMPREF3202_00451 | Phosphomethylpyrimidine kinase; KEGG: pmz:HMPREF0659_A5797 1.6e-80 thiD; phosphomethylpyrimidine kinase K00941; Psort location: Cytoplasmic, score: 8.96. | Thiamine monophosphate synthase/TENI; KEGG: pit:PIN17_A0607 8.0e-49 putative thiamine-phosphate diphosphorylase; K00788 thiamine-phosphate pyrophosphorylase. | 0.992 |
KXO18107.1 | KXO18423.1 | HMPREF3202_00447 | HMPREF3202_00081 | Phosphomethylpyrimidine kinase; KEGG: pmz:HMPREF0659_A5797 1.6e-80 thiD; phosphomethylpyrimidine kinase K00941; Psort location: Cytoplasmic, score: 8.96. | KEGG: bhl:Bache_2367 3.0e-37 phosphomethylpyrimidine kinase K00941; Psort location: Cytoplasmic, score: 9.26. | 0.834 |
KXO18107.1 | guaB | HMPREF3202_00447 | HMPREF3202_01042 | Phosphomethylpyrimidine kinase; KEGG: pmz:HMPREF0659_A5797 1.6e-80 thiD; phosphomethylpyrimidine kinase K00941; Psort location: Cytoplasmic, score: 8.96. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.665 |
KXO18107.1 | pdxS | HMPREF3202_00447 | HMPREF3202_00080 | Phosphomethylpyrimidine kinase; KEGG: pmz:HMPREF0659_A5797 1.6e-80 thiD; phosphomethylpyrimidine kinase K00941; Psort location: Cytoplasmic, score: 8.96. | Pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | 0.475 |
KXO18107.1 | pdxT | HMPREF3202_00447 | HMPREF3202_00079 | Phosphomethylpyrimidine kinase; KEGG: pmz:HMPREF0659_A5797 1.6e-80 thiD; phosphomethylpyrimidine kinase K00941; Psort location: Cytoplasmic, score: 8.96. | Pyridoxal 5'-phosphate synthase, glutaminase subunit Pdx2; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | 0.455 |
KXO18107.1 | thi4 | HMPREF3202_00447 | HMPREF3202_00450 | Phosphomethylpyrimidine kinase; KEGG: pmz:HMPREF0659_A5797 1.6e-80 thiD; phosphomethylpyrimidine kinase K00941; Psort location: Cytoplasmic, score: 8.96. | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.897 |
KXO18107.1 | thiC | HMPREF3202_00447 | HMPREF3202_00449 | Phosphomethylpyrimidine kinase; KEGG: pmz:HMPREF0659_A5797 1.6e-80 thiD; phosphomethylpyrimidine kinase K00941; Psort location: Cytoplasmic, score: 8.96. | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.994 |
KXO18107.1 | thiE | HMPREF3202_00447 | HMPREF3202_00448 | Phosphomethylpyrimidine kinase; KEGG: pmz:HMPREF0659_A5797 1.6e-80 thiD; phosphomethylpyrimidine kinase K00941; Psort location: Cytoplasmic, score: 8.96. | Putative thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.999 |
KXO18107.1 | thiL | HMPREF3202_00447 | HMPREF3202_02481 | Phosphomethylpyrimidine kinase; KEGG: pmz:HMPREF0659_A5797 1.6e-80 thiD; phosphomethylpyrimidine kinase K00941; Psort location: Cytoplasmic, score: 8.96. | Thiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.481 |
KXO18111.1 | KXO18107.1 | HMPREF3202_00451 | HMPREF3202_00447 | Thiamine monophosphate synthase/TENI; KEGG: pit:PIN17_A0607 8.0e-49 putative thiamine-phosphate diphosphorylase; K00788 thiamine-phosphate pyrophosphorylase. | Phosphomethylpyrimidine kinase; KEGG: pmz:HMPREF0659_A5797 1.6e-80 thiD; phosphomethylpyrimidine kinase K00941; Psort location: Cytoplasmic, score: 8.96. | 0.992 |
KXO18111.1 | KXO18423.1 | HMPREF3202_00451 | HMPREF3202_00081 | Thiamine monophosphate synthase/TENI; KEGG: pit:PIN17_A0607 8.0e-49 putative thiamine-phosphate diphosphorylase; K00788 thiamine-phosphate pyrophosphorylase. | KEGG: bhl:Bache_2367 3.0e-37 phosphomethylpyrimidine kinase K00941; Psort location: Cytoplasmic, score: 9.26. | 0.804 |
KXO18111.1 | guaB | HMPREF3202_00451 | HMPREF3202_01042 | Thiamine monophosphate synthase/TENI; KEGG: pit:PIN17_A0607 8.0e-49 putative thiamine-phosphate diphosphorylase; K00788 thiamine-phosphate pyrophosphorylase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.448 |
KXO18111.1 | thi4 | HMPREF3202_00451 | HMPREF3202_00450 | Thiamine monophosphate synthase/TENI; KEGG: pit:PIN17_A0607 8.0e-49 putative thiamine-phosphate diphosphorylase; K00788 thiamine-phosphate pyrophosphorylase. | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.695 |
KXO18111.1 | thiC | HMPREF3202_00451 | HMPREF3202_00449 | Thiamine monophosphate synthase/TENI; KEGG: pit:PIN17_A0607 8.0e-49 putative thiamine-phosphate diphosphorylase; K00788 thiamine-phosphate pyrophosphorylase. | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.933 |
KXO18111.1 | thiE | HMPREF3202_00451 | HMPREF3202_00448 | Thiamine monophosphate synthase/TENI; KEGG: pit:PIN17_A0607 8.0e-49 putative thiamine-phosphate diphosphorylase; K00788 thiamine-phosphate pyrophosphorylase. | Putative thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.982 |
KXO18111.1 | thiL | HMPREF3202_00451 | HMPREF3202_02481 | Thiamine monophosphate synthase/TENI; KEGG: pit:PIN17_A0607 8.0e-49 putative thiamine-phosphate diphosphorylase; K00788 thiamine-phosphate pyrophosphorylase. | Thiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.941 |
KXO18423.1 | KXO18107.1 | HMPREF3202_00081 | HMPREF3202_00447 | KEGG: bhl:Bache_2367 3.0e-37 phosphomethylpyrimidine kinase K00941; Psort location: Cytoplasmic, score: 9.26. | Phosphomethylpyrimidine kinase; KEGG: pmz:HMPREF0659_A5797 1.6e-80 thiD; phosphomethylpyrimidine kinase K00941; Psort location: Cytoplasmic, score: 8.96. | 0.834 |
KXO18423.1 | KXO18111.1 | HMPREF3202_00081 | HMPREF3202_00451 | KEGG: bhl:Bache_2367 3.0e-37 phosphomethylpyrimidine kinase K00941; Psort location: Cytoplasmic, score: 9.26. | Thiamine monophosphate synthase/TENI; KEGG: pit:PIN17_A0607 8.0e-49 putative thiamine-phosphate diphosphorylase; K00788 thiamine-phosphate pyrophosphorylase. | 0.804 |
KXO18423.1 | guaB | HMPREF3202_00081 | HMPREF3202_01042 | KEGG: bhl:Bache_2367 3.0e-37 phosphomethylpyrimidine kinase K00941; Psort location: Cytoplasmic, score: 9.26. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.665 |
KXO18423.1 | metG | HMPREF3202_00081 | HMPREF3202_00082 | KEGG: bhl:Bache_2367 3.0e-37 phosphomethylpyrimidine kinase K00941; Psort location: Cytoplasmic, score: 9.26. | methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.486 |