STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KXO18360.1ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; KEGG: pdn:HMPREF9137_0626 0. DNA topoisomerase IV subunit B; K02622 topoisomerase IV subunit B; Psort location: Cytoplasmic, score: 9.97. (648 aa)    
Predicted Functional Partners:
KXO17287.1
KEGG: pmz:HMPREF0659_A6144 0. DNA gyrase/topoisomerase IV, A subunit; K02621 topoisomerase IV subunit A; Psort location: Cytoplasmic, score: 9.97.
 
 
 0.955
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
 0.920
KXO17328.1
Hypothetical protein.
  
 
 0.778
KXO17329.1
Hypothetical protein.
  
 
 0.778
KXO16641.1
Hypothetical protein.
  
 
 0.778
KXO16642.1
Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.
  
 
 0.778
KXO15742.1
Hypothetical protein.
  
 
 0.778
KXO15743.1
Transposase, IS4 family; Psort location: Cytoplasmic, score: 8.96.
  
 
 0.778
KXO15618.1
Hypothetical protein.
  
 
 0.778
KXO18361.1
Peptidase, S41 family; KEGG: pdn:HMPREF9137_0624 2.2e-204 peptidase, S41 family K03797; Psort location: CytoplasmicMembrane, score: 9.99; Belongs to the peptidase S41A family.
       0.767
Your Current Organism:
Prevotella bivia
NCBI taxonomy Id: 28125
Other names: ATCC 29303, Bacteroides bivius, CCUG 9557, CIP 105105, DSM 20514, JCM 6331, LMG 6452, LMG:6452, NCTC 11156, P. bivia, VPI 6822, strain 653C, strain JCVIHMP010
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.