Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dnaKChaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (633 aa)    
Predicted Functional Partners:
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
 0.996
grpE
Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]
 
 0.996
KXA42240.1
Hsp90 protein; KEGG: eci:UTI89_C0501 6.4e-63 htpG; heat shock protein 90 K04079; Psort location: Cytoplasmic, score: 9.97.
   
 0.992
groL
Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 0.988
groS
Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
 
 
 0.980
KXA39755.1
DnaJ domain protein; KEGG: apb:SAR116_1614 3.6e-26 DnaJ family molecular chaperone K03686; Psort location: Cytoplasmic, score: 9.26.
 
 0.975
KXA38623.1
DnaJ domain protein; KEGG: tgo:TGME49_017710 0.00030 DnaJ domain-containing protein; Psort location: CytoplasmicMembrane, score: 9.82.
 
 0.947
KXA43880.1
Tetratricopeptide repeat protein; KEGG: ipa:Isop_1658 5.8e-06 RNA polymerase subunit alpha domain-containing protein; K03040 DNA-directed RNA polymerase subunit alpha.
  
 0.914
KXA37785.1
KEGG: pit:PIN17_0051 2.5e-267 respiratory-chain NADH dehydrogenase, 30 Kd subunit; K13378 NADH-quinone oxidoreductase subunit C/D; Psort location: Cytoplasmic, score: 9.97.
    
 0.914
lon
Endopeptidase La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
 
 0.910
Your Current Organism:
Prevotella corporis
NCBI taxonomy Id: 28128
Other names: ATCC 33547, Bacteroides corporis, CIP 105107, DSM 18810, JCM 8529, NCTC 13065, P. corporis, VPI 9342, strain Lambe 532-70A
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