Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KXA33385.1KEGG: pmz:HMPREF0659_A6144 0. DNA gyrase/topoisomerase IV, A subunit; K02621 topoisomerase IV subunit A; Psort location: Cytoplasmic, score: 9.97. (918 aa)    
Predicted Functional Partners:
KXA42351.1
ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; KEGG: pmz:HMPREF0659_A5055 0. DNA topoisomerase IV subunit B; K02622 topoisomerase IV subunit B; Psort location: Cytoplasmic, score: 9.97.
 
 
 0.972
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
 
 0.927
KXA33386.1
Hypothetical protein.
       0.816
KXA33387.1
Peptidase, S41 family; KEGG: kse:Ksed_08930 1.4e-11 periplasmic protease; K03797 carboxyl-terminal processing protease.
  
    0.816
secD
Export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily.
 
  
 0.642
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
  
 
0.625
metG
methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
  
 0.606
rpsO
Ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
   
   0.596
argS
arginine--tRNA ligase; KEGG: pit:PIN17_A0674 8.6e-297 argS; arginine--tRNA ligase K01887; Psort location: Cytoplasmic, score: 9.97.
  
  
 0.518
nusA
Transcription termination factor NusA; Participates in both transcription termination and antitermination.
  
  
 0.476
Your Current Organism:
Prevotella corporis
NCBI taxonomy Id: 28128
Other names: ATCC 33547, Bacteroides corporis, CIP 105107, DSM 18810, JCM 8529, NCTC 13065, P. corporis, VPI 9342, strain Lambe 532-70A
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