| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KXA35369.1 | KXA35393.1 | HMPREF3226_02056 | HMPREF3226_02081 | KEGG: pit:PIN17_A1996 3.0e-88 MGS-like domain protein; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | KEGG: pit:PIN17_A1098 7.1e-199 AICARFT/IMPCHase bienzyme; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | 0.900 |
| KXA35369.1 | KXA43018.1 | HMPREF3226_02056 | HMPREF3226_00553 | KEGG: pit:PIN17_A1996 3.0e-88 MGS-like domain protein; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | KEGG: pit:PIN17_A1822 8.9e-279 ftcD; glutamate formimidoyltransferase; Psort location: Cytoplasmic, score: 9.97. | 0.655 |
| KXA35369.1 | KXA45078.1 | HMPREF3226_02056 | HMPREF3226_00044 | KEGG: pit:PIN17_A1996 3.0e-88 MGS-like domain protein; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.513 |
| KXA35369.1 | fhs | HMPREF3226_02056 | HMPREF3226_02495 | KEGG: pit:PIN17_A1996 3.0e-88 MGS-like domain protein; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | KEGG: pit:PIN17_A0100 3.3e-240 fhs; formate--tetrahydrofolate ligase K01938; Psort location: Cytoplasmic, score: 8.96. | 0.784 |
| KXA35369.1 | fmt | HMPREF3226_02056 | HMPREF3226_01726 | KEGG: pit:PIN17_A1996 3.0e-88 MGS-like domain protein; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.542 |
| KXA35369.1 | folD | HMPREF3226_02056 | HMPREF3226_00572 | KEGG: pit:PIN17_A1996 3.0e-88 MGS-like domain protein; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.784 |
| KXA35369.1 | gcvT | HMPREF3226_02056 | HMPREF3226_00124 | KEGG: pit:PIN17_A1996 3.0e-88 MGS-like domain protein; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.582 |
| KXA35369.1 | glyA | HMPREF3226_02056 | HMPREF3226_02394 | KEGG: pit:PIN17_A1996 3.0e-88 MGS-like domain protein; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.829 |
| KXA35369.1 | purL | HMPREF3226_02056 | HMPREF3226_01210 | KEGG: pit:PIN17_A1996 3.0e-88 MGS-like domain protein; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | Putative phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.993 |
| KXA35369.1 | purN | HMPREF3226_02056 | HMPREF3226_01519 | KEGG: pit:PIN17_A1996 3.0e-88 MGS-like domain protein; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | Putative phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.987 |
| KXA35393.1 | KXA35369.1 | HMPREF3226_02081 | HMPREF3226_02056 | KEGG: pit:PIN17_A1098 7.1e-199 AICARFT/IMPCHase bienzyme; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | KEGG: pit:PIN17_A1996 3.0e-88 MGS-like domain protein; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | 0.900 |
| KXA35393.1 | KXA43018.1 | HMPREF3226_02081 | HMPREF3226_00553 | KEGG: pit:PIN17_A1098 7.1e-199 AICARFT/IMPCHase bienzyme; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | KEGG: pit:PIN17_A1822 8.9e-279 ftcD; glutamate formimidoyltransferase; Psort location: Cytoplasmic, score: 9.97. | 0.837 |
| KXA35393.1 | KXA45078.1 | HMPREF3226_02081 | HMPREF3226_00044 | KEGG: pit:PIN17_A1098 7.1e-199 AICARFT/IMPCHase bienzyme; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.842 |
| KXA35393.1 | fhs | HMPREF3226_02081 | HMPREF3226_02495 | KEGG: pit:PIN17_A1098 7.1e-199 AICARFT/IMPCHase bienzyme; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | KEGG: pit:PIN17_A0100 3.3e-240 fhs; formate--tetrahydrofolate ligase K01938; Psort location: Cytoplasmic, score: 8.96. | 0.930 |
| KXA35393.1 | fmt | HMPREF3226_02081 | HMPREF3226_01726 | KEGG: pit:PIN17_A1098 7.1e-199 AICARFT/IMPCHase bienzyme; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.868 |
| KXA35393.1 | folD | HMPREF3226_02081 | HMPREF3226_00572 | KEGG: pit:PIN17_A1098 7.1e-199 AICARFT/IMPCHase bienzyme; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.911 |
| KXA35393.1 | gcvT | HMPREF3226_02081 | HMPREF3226_00124 | KEGG: pit:PIN17_A1098 7.1e-199 AICARFT/IMPCHase bienzyme; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.864 |
| KXA35393.1 | glyA | HMPREF3226_02081 | HMPREF3226_02394 | KEGG: pit:PIN17_A1098 7.1e-199 AICARFT/IMPCHase bienzyme; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.944 |
| KXA35393.1 | purL | HMPREF3226_02081 | HMPREF3226_01210 | KEGG: pit:PIN17_A1098 7.1e-199 AICARFT/IMPCHase bienzyme; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | Putative phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.993 |
| KXA35393.1 | purN | HMPREF3226_02081 | HMPREF3226_01519 | KEGG: pit:PIN17_A1098 7.1e-199 AICARFT/IMPCHase bienzyme; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. | Putative phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.982 |
