| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APW33680.1 | APW33683.1 | BWX40_01760 | BWX40_01775 | Membrane protein insertion efficiency factor YidD; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | DUF4271 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.692 |
| APW33680.1 | HemD | BWX40_01760 | BWX40_01770 | Membrane protein insertion efficiency factor YidD; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | uroporphyrinogen-III synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.692 |
| APW33680.1 | metK | BWX40_01760 | BWX40_01780 | Membrane protein insertion efficiency factor YidD; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.692 |
| APW33680.1 | rnpA | BWX40_01760 | BWX40_01765 | Membrane protein insertion efficiency factor YidD; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.979 |
| APW33683.1 | APW33680.1 | BWX40_01775 | BWX40_01760 | DUF4271 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Membrane protein insertion efficiency factor YidD; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | 0.692 |
| APW33683.1 | HemD | BWX40_01775 | BWX40_01770 | DUF4271 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | uroporphyrinogen-III synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.820 |
| APW33683.1 | metK | BWX40_01775 | BWX40_01780 | DUF4271 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.820 |
| APW33683.1 | rnpA | BWX40_01775 | BWX40_01765 | DUF4271 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.692 |
| APW34904.1 | metK | BWX40_08755 | BWX40_01780 | GAF domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.900 |
| CoaBC | metK | BWX40_09645 | BWX40_01780 | Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.772 |
| HemD | APW33680.1 | BWX40_01770 | BWX40_01760 | uroporphyrinogen-III synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Membrane protein insertion efficiency factor YidD; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | 0.692 |
| HemD | APW33683.1 | BWX40_01770 | BWX40_01775 | uroporphyrinogen-III synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | DUF4271 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.820 |
| HemD | metK | BWX40_01770 | BWX40_01780 | uroporphyrinogen-III synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.840 |
| HemD | rnpA | BWX40_01770 | BWX40_01765 | uroporphyrinogen-III synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.858 |
| glyA | metK | BWX40_10580 | BWX40_01780 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.622 |
| ispF | metK | BWX40_09230 | BWX40_01780 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.778 |
| metK | APW33680.1 | BWX40_01780 | BWX40_01760 | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Membrane protein insertion efficiency factor YidD; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | 0.692 |
| metK | APW33683.1 | BWX40_01780 | BWX40_01775 | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | DUF4271 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.820 |
| metK | APW34904.1 | BWX40_01780 | BWX40_08755 | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | GAF domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.900 |
| metK | CoaBC | BWX40_01780 | BWX40_09645 | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.772 |
