node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apt | gmk | BWX40_01160 | BWX40_00035 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.944 |
apt | guaA | BWX40_01160 | BWX40_04925 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | 0.979 |
apt | guaB | BWX40_01160 | BWX40_08920 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.496 |
apt | purL | BWX40_01160 | BWX40_00050 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.687 |
apt | pyrG | BWX40_01160 | BWX40_07315 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.401 |
apt | xpt | BWX40_01160 | BWX40_07835 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.900 |
argS | gmk | BWX40_01875 | BWX40_00035 | arginine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.592 |
argS | guaA | BWX40_01875 | BWX40_04925 | arginine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | 0.986 |
argS | lysS | BWX40_01875 | BWX40_04050 | arginine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. | lysine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.767 |
argS | purL | BWX40_01875 | BWX40_00050 | arginine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.543 |
argS | pyrG | BWX40_01875 | BWX40_07315 | arginine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.653 |
argS | rplK | BWX40_01875 | BWX40_03330 | arginine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.482 |
gmk | apt | BWX40_00035 | BWX40_01160 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.944 |
gmk | argS | BWX40_00035 | BWX40_01875 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | arginine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.592 |
gmk | guaA | BWX40_00035 | BWX40_04925 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | 0.958 |
gmk | guaB | BWX40_00035 | BWX40_08920 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.495 |
gmk | purL | BWX40_00035 | BWX40_00050 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.642 |
gmk | xpt | BWX40_00035 | BWX40_07835 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.944 |
guaA | apt | BWX40_04925 | BWX40_01160 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.979 |
guaA | argS | BWX40_04925 | BWX40_01875 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | arginine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.986 |