node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKE93156.1 | AKE93157.1 | CSK29544_00191 | CSK29544_00192 | Acetolactate synthase small subunit. | Acetolactate synthase large subunit. | 0.999 |
AKE93156.1 | AKE93708.1 | CSK29544_00191 | CSK29544_00745 | Acetolactate synthase small subunit. | Acetolactate synthase large subunit. | 0.997 |
AKE93156.1 | AKE94840.1 | CSK29544_00191 | CSK29544_01882 | Acetolactate synthase small subunit. | Thiamine pyrophosphate protein; Belongs to the TPP enzyme family. | 0.978 |
AKE93156.1 | AKE95893.1 | CSK29544_00191 | CSK29544_02942 | Acetolactate synthase small subunit. | Pyruvate-flavodoxin oxidoreductase. | 0.936 |
AKE93156.1 | AKE96717.1 | CSK29544_00191 | CSK29544_03772 | Acetolactate synthase small subunit. | Pyruvate dehydrogenase; Belongs to the TPP enzyme family. | 0.979 |
AKE93156.1 | alsS | CSK29544_00191 | CSK29544_02068 | Acetolactate synthase small subunit. | Acetolactate synthase; Belongs to the TPP enzyme family. | 0.988 |
AKE93156.1 | ilvA | CSK29544_00191 | CSK29544_00741 | Acetolactate synthase small subunit. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.981 |
AKE93156.1 | ilvC | CSK29544_00191 | CSK29544_00739 | Acetolactate synthase small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.993 |
AKE93156.1 | leuA | CSK29544_00191 | CSK29544_00197 | Acetolactate synthase small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.970 |
AKE93156.1 | leuB | CSK29544_00191 | CSK29544_00198 | Acetolactate synthase small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.991 |
AKE93157.1 | AKE93156.1 | CSK29544_00192 | CSK29544_00191 | Acetolactate synthase large subunit. | Acetolactate synthase small subunit. | 0.999 |
AKE93157.1 | AKE93708.1 | CSK29544_00192 | CSK29544_00745 | Acetolactate synthase large subunit. | Acetolactate synthase large subunit. | 0.907 |
AKE93157.1 | AKE94840.1 | CSK29544_00192 | CSK29544_01882 | Acetolactate synthase large subunit. | Thiamine pyrophosphate protein; Belongs to the TPP enzyme family. | 0.849 |
AKE93157.1 | AKE95893.1 | CSK29544_00192 | CSK29544_02942 | Acetolactate synthase large subunit. | Pyruvate-flavodoxin oxidoreductase. | 0.949 |
AKE93157.1 | AKE96717.1 | CSK29544_00192 | CSK29544_03772 | Acetolactate synthase large subunit. | Pyruvate dehydrogenase; Belongs to the TPP enzyme family. | 0.849 |
AKE93157.1 | alsS | CSK29544_00192 | CSK29544_02068 | Acetolactate synthase large subunit. | Acetolactate synthase; Belongs to the TPP enzyme family. | 0.924 |
AKE93157.1 | ilvA | CSK29544_00192 | CSK29544_00741 | Acetolactate synthase large subunit. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.937 |
AKE93157.1 | ilvC | CSK29544_00192 | CSK29544_00739 | Acetolactate synthase large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.977 |
AKE93157.1 | leuA | CSK29544_00192 | CSK29544_00197 | Acetolactate synthase large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.959 |
AKE93157.1 | leuB | CSK29544_00192 | CSK29544_00198 | Acetolactate synthase large subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.981 |