STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hypAHydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (115 aa)    
Predicted Functional Partners:
hypB
hypB: hydrogenase accessory protein HypB; [OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase.
 
 
 0.955
hypC
hypC_hupF: hydrogenase assembly chaperone HypC/HupF; [O] COG0298 Hydrogenase maturation factor.
 
  
 0.933
hybC_1
Nickel-dependent hydrogenase family protein; [C] COG0374 Ni,Fe-hydrogenase I large subunit.
 
 
 0.931
hypE
hypE: hydrogenase expression/formation protein HypE; [O] COG0309 Hydrogenase maturation factor.
 
  
 0.858
hypD
hypD: hydrogenase expression/formation protein HypD; [O] COG0409 Hydrogenase maturation factor; Belongs to the HypD family.
 
  
 0.853
hypF
Carbamoyltransferase HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
   
 0.845
hypC-2
hypC_hupF: hydrogenase assembly chaperone HypC/HupF; [O] COG0298 Hydrogenase maturation factor.
 
  
 0.829
ureG
Urease accessory protein UreG; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
  
 
 0.811
hybD
hupD: hydrogenase expression/formation protein; [C] COG0680 Ni,Fe-hydrogenase maturation factor.
 
  
 0.793
hyb0
hydA: hydrogenase family protein; [C] COG1740 Ni,Fe-hydrogenase I small subunit.
 
  
 0.770
Your Current Organism:
Yersinia kristensenii
NCBI taxonomy Id: 28152
Other names: ATCC 33638, CCUG 11294, CCUG 8241, CIP 80.30, DSM 18543, JCM 7576, NCTC 11471, Y. kristensenii, strain 105
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.