node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fdx | hscA | CH54_1461 | CH54_1462 | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system; [C] COG0633 Ferredoxin. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | 0.988 |
fdx | hscB | CH54_1461 | CH54_1463 | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system; [C] COG0633 Ferredoxin. | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.988 |
fdx | iscA | CH54_1461 | CH54_1465 | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system; [C] COG0633 Ferredoxin. | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. | 0.959 |
fdx | iscR | CH54_1461 | CH54_1468 | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system; [C] COG0633 Ferredoxin. | Iron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.660 |
fdx | iscS | CH54_1461 | CH54_1467 | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system; [C] COG0633 Ferredoxin. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.976 |
fdx | iscU | CH54_1461 | CH54_1466 | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system; [C] COG0633 Ferredoxin. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.990 |
fdx | nfuA | CH54_1461 | CH54_2333 | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system; [C] COG0633 Ferredoxin. | nifU-like domain protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.593 |
fdx | sufA | CH54_1461 | CH54_283 | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system; [C] COG0633 Ferredoxin. | Iron-sulfur cluster assembly accessory family protein; [S] COG0316 Uncharacterized conserved protein; Belongs to the HesB/IscA family. | 0.840 |
fliG_2 | iscR | CH54_3188 | CH54_1468 | fliG middle domain protein; [N] COG1536 Flagellar motor switch protein. | Iron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.528 |
hscA | fdx | CH54_1462 | CH54_1461 | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system; [C] COG0633 Ferredoxin. | 0.988 |
hscA | hscB | CH54_1462 | CH54_1463 | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.994 |
hscA | iscA | CH54_1462 | CH54_1465 | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. | 0.840 |
hscA | iscR | CH54_1462 | CH54_1468 | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | Iron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.584 |
hscA | iscS | CH54_1462 | CH54_1467 | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.875 |
hscA | iscU | CH54_1462 | CH54_1466 | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.973 |
hscA | nfuA | CH54_1462 | CH54_2333 | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | nifU-like domain protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.537 |
hscA | sufA | CH54_1462 | CH54_283 | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | Iron-sulfur cluster assembly accessory family protein; [S] COG0316 Uncharacterized conserved protein; Belongs to the HesB/IscA family. | 0.591 |
hscB | fdx | CH54_1463 | CH54_1461 | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system; [C] COG0633 Ferredoxin. | 0.988 |
hscB | hscA | CH54_1463 | CH54_1462 | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | 0.994 |
hscB | iscA | CH54_1463 | CH54_1465 | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. | 0.978 |