STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
degPdegP_htrA_DO: peptidase Do family protein; [O] COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; Belongs to the peptidase S1C family. (480 aa)    
Predicted Functional Partners:
mclA
Hypothetical protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrad [...]
  
 
 0.795
ompA1
ompA-like transmembrane domain protein; [M] COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; Belongs to the outer membrane OOP (TC 1.B.6) superfamily.
   
 
 0.760
ompD
[M] COG3203 Outer membrane protein (porin).
  
 
 
 0.750
arcB
Sensory box protein; [T] COG0642 Signal transduction histidine kinase.
 
  
 0.733
b0053
PPIC-type PPIASE domain protein; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
     
 0.712
fkpA
Domain amino terminal to FKBP-type peptidyl-prolyl isomerase family protein; [O] COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1.
   
 
 0.708
ompF
[M] COG3203 Outer membrane protein (porin).
  
 
 
 0.679
yaeT
Outer membrane assembly complex, YaeT protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery.
  
   
 0.658
meoA
[M] COG3203 Outer membrane protein (porin); Belongs to the Gram-negative porin family.
  
 
 
 0.618
rplI
Ribosomal protein L9; Binds to the 23S rRNA.
 
 
   0.579
Your Current Organism:
Yersinia kristensenii
NCBI taxonomy Id: 28152
Other names: ATCC 33638, CCUG 11294, CCUG 8241, CIP 80.30, DSM 18543, JCM 7576, NCTC 11471, Y. kristensenii, strain 105
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