STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemLhemL: glutamate-1-semialdehyde-2,1-aminomutase; [H] COG0001 Glutamate-1-semialdehyde aminotransferase. (426 aa)    
Predicted Functional Partners:
hemB
[H] COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.995
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.990
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
  
 0.953
CH54_3164
AA-adenyl-dom: amino acid adenylation domain protein; [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins.
  
 
 0.827
CH54_888
AA-adenyl-dom: amino acid adenylation domain protein; [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins.
  
 
 0.785
dltA
D-ala-DACP-lig: D-alanine--poly(phosphoribitol) ligase, subunit 1; [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins.
  
 
 0.765
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.706
glgX
Glycogen debranching enzyme GlgX; Removes maltotriose and maltotetraose chains that are attached by 1,6-alpha-linkage to the limit dextrin main chain, generating a debranched limit dextrin.
   
  
 0.674
cobA-3
cobA_cysG_Cterm: uroporphyrinogen-III C-methyltransferase; [H] COG0007 Uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family.
 
   
 0.668
cobA-2
uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
   
 0.667
Your Current Organism:
Yersinia kristensenii
NCBI taxonomy Id: 28152
Other names: ATCC 33638, CCUG 11294, CCUG 8241, CIP 80.30, DSM 18543, JCM 7576, NCTC 11471, Y. kristensenii, strain 105
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