node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CH54_391 | ilvA | CH54_391 | CH54_2731 | ACT domain protein; [E] COG0440 Acetolactate synthase, small (regulatory) subunit. | ilvA_2Cterm: threonine ammonia-lyase, biosynthetic; [E] COG1171 Threonine dehydratase. | 0.953 |
CH54_391 | ilvB | CH54_391 | CH54_1792 | ACT domain protein; [E] COG0440 Acetolactate synthase, small (regulatory) subunit. | Acolac_lg: acetolactate synthase, large subunit, biosynthetic type; [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | 0.991 |
CH54_391 | ilvB-2 | CH54_391 | CH54_2727 | ACT domain protein; [E] COG0440 Acetolactate synthase, small (regulatory) subunit. | Acolac_lg: acetolactate synthase, large subunit, biosynthetic type; [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | 0.991 |
CH54_391 | ilvC | CH54_391 | CH54_2733 | ACT domain protein; [E] COG0440 Acetolactate synthase, small (regulatory) subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.987 |
CH54_391 | ilvD | CH54_391 | CH54_2730 | ACT domain protein; [E] COG0440 Acetolactate synthase, small (regulatory) subunit. | ilvD: dihydroxy-acid dehydratase; [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.696 |
CH54_391 | ilvM | CH54_391 | CH54_2728 | ACT domain protein; [E] COG0440 Acetolactate synthase, small (regulatory) subunit. | ACT domain protein; [S] COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit. | 0.918 |
CH54_391 | ilvN | CH54_391 | CH54_1791 | ACT domain protein; [E] COG0440 Acetolactate synthase, small (regulatory) subunit. | Acolac_sm: acetolactate synthase, small subunit; [E] COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.919 |
CH54_391 | leuA | CH54_391 | CH54_1796 | ACT domain protein; [E] COG0440 Acetolactate synthase, small (regulatory) subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.960 |
CH54_391 | leuB | CH54_391 | CH54_1797 | ACT domain protein; [E] COG0440 Acetolactate synthase, small (regulatory) subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.986 |
CH54_391 | tdcB | CH54_391 | CH54_2490 | ACT domain protein; [E] COG0440 Acetolactate synthase, small (regulatory) subunit. | Pyridoxal-phosphate dependent enzyme family protein; [E] COG1171 Threonine dehydratase. | 0.953 |
ilvA | CH54_391 | CH54_2731 | CH54_391 | ilvA_2Cterm: threonine ammonia-lyase, biosynthetic; [E] COG1171 Threonine dehydratase. | ACT domain protein; [E] COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.953 |
ilvA | ilvB | CH54_2731 | CH54_1792 | ilvA_2Cterm: threonine ammonia-lyase, biosynthetic; [E] COG1171 Threonine dehydratase. | Acolac_lg: acetolactate synthase, large subunit, biosynthetic type; [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | 0.928 |
ilvA | ilvB-2 | CH54_2731 | CH54_2727 | ilvA_2Cterm: threonine ammonia-lyase, biosynthetic; [E] COG1171 Threonine dehydratase. | Acolac_lg: acetolactate synthase, large subunit, biosynthetic type; [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | 0.962 |
ilvA | ilvC | CH54_2731 | CH54_2733 | ilvA_2Cterm: threonine ammonia-lyase, biosynthetic; [E] COG1171 Threonine dehydratase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.637 |
ilvA | ilvD | CH54_2731 | CH54_2730 | ilvA_2Cterm: threonine ammonia-lyase, biosynthetic; [E] COG1171 Threonine dehydratase. | ilvD: dihydroxy-acid dehydratase; [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.943 |
ilvA | ilvM | CH54_2731 | CH54_2728 | ilvA_2Cterm: threonine ammonia-lyase, biosynthetic; [E] COG1171 Threonine dehydratase. | ACT domain protein; [S] COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit. | 0.959 |
ilvA | ilvN | CH54_2731 | CH54_1791 | ilvA_2Cterm: threonine ammonia-lyase, biosynthetic; [E] COG1171 Threonine dehydratase. | Acolac_sm: acetolactate synthase, small subunit; [E] COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.965 |
ilvA | leuA | CH54_2731 | CH54_1796 | ilvA_2Cterm: threonine ammonia-lyase, biosynthetic; [E] COG1171 Threonine dehydratase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.523 |
ilvA | leuB | CH54_2731 | CH54_1797 | ilvA_2Cterm: threonine ammonia-lyase, biosynthetic; [E] COG1171 Threonine dehydratase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.958 |
ilvA | tdcB | CH54_2731 | CH54_2490 | ilvA_2Cterm: threonine ammonia-lyase, biosynthetic; [E] COG1171 Threonine dehydratase. | Pyridoxal-phosphate dependent enzyme family protein; [E] COG1171 Threonine dehydratase. | 0.917 |