STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lsrGAntibiotic biosynthesis monooxygenase family protein; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5- phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5- phosphonooxypentane-2,4-dione (P-HPD); Belongs to the LsrG family. (96 aa)    
Predicted Functional Partners:
lsrF
deoC/LacD aldolase family protein; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5- phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA; Belongs to the DeoC/FbaB aldolase family.
 
 
 0.991
lsrB_1
Periplasmic binding domain protein; [G] COG1879 ABC-type sugar transport system, periplasmic component.
 
  
 0.981
lsrD_1
[G] COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components.
 
  
 0.957
xylB3_1
Hypothetical protein; Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position.
 
 
 0.919
lsrB_2
Periplasmic binding domain protein; [G] COG1879 ABC-type sugar transport system, periplasmic component.
 
  
 0.881
ydeW
Putative sugar-binding domain protein; [K] COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain.
 
  
 0.842
lsrC
[G] COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components.
 
  
 0.764
ccmA-4
ccmA: heme ABC exporter, ATP-binding protein CcmA; [G] COG1129 ABC-type sugar transport system, ATPase component.
  
  
 0.637
CH54_1247
Bacterial regulatory s, tetR family protein; [K] COG1309 Transcriptional regulator.
  
     0.547
luxS
S-Ribosylhomocysteinase family protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
  
  
 0.488
Your Current Organism:
Yersinia kristensenii
NCBI taxonomy Id: 28152
Other names: ATCC 33638, CCUG 11294, CCUG 8241, CIP 80.30, DSM 18543, JCM 7576, NCTC 11471, Y. kristensenii, strain 105
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.