Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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lsrGAntibiotic biosynthesis monooxygenase family protein; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5- phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5- phosphonooxypentane-2,4-dione (P-HPD); Belongs to the LsrG family. (96 aa)    
Predicted Functional Partners:
lsrF
deoC/LacD aldolase family protein; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5- phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA; Belongs to the DeoC/FbaB aldolase family.
 
 
 0.997
lsrB_1
Periplasmic binding domain protein; [G] COG1879 ABC-type sugar transport system, periplasmic component.
 
  
 0.978
lsrD_1
[G] COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components.
 
  
 0.973
xylB3_1
Hypothetical protein; Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position.
 
 
 0.945
lsrB_2
Periplasmic binding domain protein; [G] COG1879 ABC-type sugar transport system, periplasmic component.
 
  
 0.914
ydeW
Putative sugar-binding domain protein; [K] COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain.
 
  
 0.882
lsrC
[G] COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components.
 
  
 0.822
ccmA-4
ccmA: heme ABC exporter, ATP-binding protein CcmA; [G] COG1129 ABC-type sugar transport system, ATPase component.
  
  
 0.720
luxS
S-Ribosylhomocysteinase family protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
  
  
 0.604
CH54_1646
Putative sugar-binding domain protein; [K] COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain.
 
  
 0.585
Your Current Organism:
Yersinia kristensenii
NCBI taxonomy Id: 28152
Other names: ATCC 33638, CCUG 11294, CCUG 8241, CIP 80.30, DSM 18543, JCM 7576, NCTC 11471, Y. kristensenii, strain 105
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