Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tusESulfur relay, TusE/DsrC/DsvC family protein; Part of a sulfur-relay system. (109 aa)    
Predicted Functional Partners:
tusD
dsrE/DsrF-like family protein; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE.
 
 
 0.991
trmU
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs; Belongs to the MnmA/TRMU family.
   
 0.951
tusC
Sulfur relay protein TusC/DsrF; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
 
  
 0.877
dsrH
Sulfur relay protein TusB/DsrH; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
  
 
 0.872
CH54_1059
Glycosyl transferase family, helical bundle domain protein; [E] COG0547 Anthranilate phosphoribosyltransferase.
  
    0.656
tusA
Sulfurtransferase TusA family protein; Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.
  
   
 0.540
ttcA
PP-loop family protein; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
     
 0.443
CH54_281
Hypothetical protein; FAD linked oxidase, C-terminal domain protein; [C] COG0277 FAD/FMN-containing dehydrogenases.
   
 
 0.403
Your Current Organism:
Yersinia kristensenii
NCBI taxonomy Id: 28152
Other names: ATCC 33638, CCUG 11294, CCUG 8241, CIP 80.30, DSM 18543, JCM 7576, NCTC 11471, Y. kristensenii, strain 105
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