node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acrR5 | metJ | CH54_2712 | CH54_2691 | Bacterial regulatory s, tetR family protein; Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | Met Apo-repressor, MetJ family protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | 0.745 |
acrR5 | mutH | CH54_2712 | CH54_3483 | Bacterial regulatory s, tetR family protein; Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | DNA mismatch repair endonuclease MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. Belongs to the MutH family. | 0.618 |
acrR5 | rraB | CH54_2712 | CH54_1935 | Bacterial regulatory s, tetR family protein; Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | Regulator of ribonuclease activity B family protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.703 |
acrR5 | seqA | CH54_2712 | CH54_1172 | Bacterial regulatory s, tetR family protein; Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | seqA family protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.714 |
acrR5 | yfbV | CH54_2712 | CH54_3915 | Bacterial regulatory s, tetR family protein; Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | Conserved hypothetical protein; [S] COG3092 Uncharacterized protein conserved in bacteria. | 0.610 |
acrR5 | yifE | CH54_2712 | CH54_2725 | Bacterial regulatory s, tetR family protein; Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | Conserved hypothetical protein; [S] COG3085 Uncharacterized protein conserved in bacteria. | 0.604 |
acrR5 | yihI | CH54_2712 | CH54_2562 | Bacterial regulatory s, tetR family protein; Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | Der GTPase activator family protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.610 |
metF | metJ | CH54_2694 | CH54_2691 | Fadh2: methylenetetrahydrofolate reductase [NAD(P)H]; [E] COG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Met Apo-repressor, MetJ family protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | 0.702 |
metF | metL | CH54_2694 | CH54_2693 | Fadh2: methylenetetrahydrofolate reductase [NAD(P)H]; [E] COG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Asp_kinase: aspartate kinase domain protein; [E] COG0527 Aspartokinases; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.943 |
metF | thrA | CH54_2694 | CH54_1848 | Fadh2: methylenetetrahydrofolate reductase [NAD(P)H]; [E] COG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Asp_kinase: aspartate kinase domain protein; [E] COG0460 Homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.905 |
metJ | acrR5 | CH54_2691 | CH54_2712 | Met Apo-repressor, MetJ family protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | Bacterial regulatory s, tetR family protein; Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | 0.745 |
metJ | metF | CH54_2691 | CH54_2694 | Met Apo-repressor, MetJ family protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | Fadh2: methylenetetrahydrofolate reductase [NAD(P)H]; [E] COG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.702 |
metJ | metL | CH54_2691 | CH54_2693 | Met Apo-repressor, MetJ family protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | Asp_kinase: aspartate kinase domain protein; [E] COG0527 Aspartokinases; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.780 |
metJ | mutH | CH54_2691 | CH54_3483 | Met Apo-repressor, MetJ family protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | DNA mismatch repair endonuclease MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. Belongs to the MutH family. | 0.729 |
metJ | rraB | CH54_2691 | CH54_1935 | Met Apo-repressor, MetJ family protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | Regulator of ribonuclease activity B family protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.745 |
metJ | seqA | CH54_2691 | CH54_1172 | Met Apo-repressor, MetJ family protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | seqA family protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.726 |
metJ | thrA | CH54_2691 | CH54_1848 | Met Apo-repressor, MetJ family protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | Asp_kinase: aspartate kinase domain protein; [E] COG0460 Homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.727 |
metJ | yfbV | CH54_2691 | CH54_3915 | Met Apo-repressor, MetJ family protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | Conserved hypothetical protein; [S] COG3092 Uncharacterized protein conserved in bacteria. | 0.713 |
metJ | yifE | CH54_2691 | CH54_2725 | Met Apo-repressor, MetJ family protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | Conserved hypothetical protein; [S] COG3085 Uncharacterized protein conserved in bacteria. | 0.696 |
metJ | yihI | CH54_2691 | CH54_2562 | Met Apo-repressor, MetJ family protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | Der GTPase activator family protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.708 |