Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sufDsufD: FeS assembly protein SufD; [O] COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component. (443 aa)    
Predicted Functional Partners:
sufB
sufB: FeS assembly protein SufB; [O] COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component.
 
 
0.999
sufC
sufC: FeS assembly ATPase SufC; [O] COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component.
 
 
 0.999
sufS
Cysteine desulfurase, SufS family protein; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo.
 
 
 0.990
sufA
Iron-sulfur cluster assembly accessory family protein; [S] COG0316 Uncharacterized conserved protein; Belongs to the HesB/IscA family.
 
 
 0.985
csdA
feS_syn_CsdA: cysteine desulfurase, catalytic subunit CsdA; [E] COG0520 Selenocysteine lyase.
 
 
 0.956
sufE
fe-S metabolism associated domain protein; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process; Belongs to the SufE family.
 
 
 0.910
iscU
FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
  
  
 0.908
csdE
feS_syn_CsdE: cysteine desulfurase, sulfur acceptor subunit CsdE; [R] COG2166 SufE protein probably involved in Fe-S center assembly.
 
 
 0.779
iscA
Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB.
  
 
 0.703
CH54_336
Pertussis toxin, subunit 1 family protein.
  
 
 0.678
Your Current Organism:
Yersinia kristensenii
NCBI taxonomy Id: 28152
Other names: ATCC 33638, CCUG 11294, CCUG 8241, CIP 80.30, DSM 18543, JCM 7576, NCTC 11471, Y. kristensenii, strain 105
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