STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hypFCarbamoyltransferase HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. (764 aa)    
Predicted Functional Partners:
hypE
hypE: hydrogenase expression/formation protein HypE; [O] COG0309 Hydrogenase maturation factor.
 
 
 0.984
hypD
hypD: hydrogenase expression/formation protein HypD; [O] COG0409 Hydrogenase maturation factor; Belongs to the HypD family.
 
  
 0.898
hypC
hypC_hupF: hydrogenase assembly chaperone HypC/HupF; [O] COG0298 Hydrogenase maturation factor.
 
 
 0.888
hypC-2
hypC_hupF: hydrogenase assembly chaperone HypC/HupF; [O] COG0298 Hydrogenase maturation factor.
 
 
 0.867
hybC_1
Nickel-dependent hydrogenase family protein; [C] COG0374 Ni,Fe-hydrogenase I large subunit.
 
 
 
 0.845
hypB
hypB: hydrogenase accessory protein HypB; [OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase.
 
   
 0.834
hypA-2
Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
   
 0.828
hypA
Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
   
 0.813
hyb0
hydA: hydrogenase family protein; [C] COG1740 Ni,Fe-hydrogenase I small subunit.
 
 
 
 0.805
hybD
hupD: hydrogenase expression/formation protein; [C] COG0680 Ni,Fe-hydrogenase maturation factor.
 
   
 0.803
Your Current Organism:
Yersinia kristensenii
NCBI taxonomy Id: 28152
Other names: ATCC 33638, CCUG 11294, CCUG 8241, CIP 80.30, DSM 18543, JCM 7576, NCTC 11471, Y. kristensenii, strain 105
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