node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CH54_3640 | dinA | CH54_3640 | CH54_1810 | Sbcc: exonuclease SbcC family protein; [L] COG0419 ATPase involved in DNA repair. | DNA polymerase family B, exonuclease domain protein; [L] COG0417 DNA polymerase elongation subunit (family B). | 0.672 |
CH54_3640 | hepA | CH54_3640 | CH54_1811 | Sbcc: exonuclease SbcC family protein; [L] COG0419 ATPase involved in DNA repair. | DEAD/DEAH box helicase family protein; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | 0.595 |
CH54_3640 | recA | CH54_3640 | CH54_1629 | Sbcc: exonuclease SbcC family protein; [L] COG0419 ATPase involved in DNA repair. | Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.810 |
CH54_3640 | recQ | CH54_3640 | CH54_2789 | Sbcc: exonuclease SbcC family protein; [L] COG0419 ATPase involved in DNA repair. | recQ: ATP-dependent DNA helicase RecQ; [L] COG0514 Superfamily II DNA helicase. | 0.890 |
CH54_3640 | sbcD | CH54_3640 | CH54_3641 | Sbcc: exonuclease SbcC family protein; [L] COG0419 ATPase involved in DNA repair. | Exonuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.999 |
CH54_3640 | ygdG | CH54_3640 | CH54_3509 | Sbcc: exonuclease SbcC family protein; [L] COG0419 ATPase involved in DNA repair. | Hypothetical protein; Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. | 0.823 |
CH54_3992 | hepA | CH54_3992 | CH54_1811 | DEAD/DEAH box helicase family protein; [KL] COG1061 DNA or RNA helicases of superfamily II. | DEAD/DEAH box helicase family protein; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | 0.909 |
CH54_3992 | ygdG | CH54_3992 | CH54_3509 | DEAD/DEAH box helicase family protein; [KL] COG1061 DNA or RNA helicases of superfamily II. | Hypothetical protein; Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. | 0.858 |
dinA | CH54_3640 | CH54_1810 | CH54_3640 | DNA polymerase family B, exonuclease domain protein; [L] COG0417 DNA polymerase elongation subunit (family B). | Sbcc: exonuclease SbcC family protein; [L] COG0419 ATPase involved in DNA repair. | 0.672 |
dinA | dnaN | CH54_1810 | CH54_2495 | DNA polymerase family B, exonuclease domain protein; [L] COG0417 DNA polymerase elongation subunit (family B). | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.989 |
dinA | hepA | CH54_1810 | CH54_1811 | DNA polymerase family B, exonuclease domain protein; [L] COG0417 DNA polymerase elongation subunit (family B). | DEAD/DEAH box helicase family protein; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | 0.822 |
dinA | mutL | CH54_1810 | CH54_2040 | DNA polymerase family B, exonuclease domain protein; [L] COG0417 DNA polymerase elongation subunit (family B). | DNA mismatch repair MutL family protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.442 |
dinA | mutS | CH54_1810 | CH54_1679 | DNA polymerase family B, exonuclease domain protein; [L] COG0417 DNA polymerase elongation subunit (family B). | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.690 |
dinA | recA | CH54_1810 | CH54_1629 | DNA polymerase family B, exonuclease domain protein; [L] COG0417 DNA polymerase elongation subunit (family B). | Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.830 |
dinA | recQ | CH54_1810 | CH54_2789 | DNA polymerase family B, exonuclease domain protein; [L] COG0417 DNA polymerase elongation subunit (family B). | recQ: ATP-dependent DNA helicase RecQ; [L] COG0514 Superfamily II DNA helicase. | 0.543 |
dinA | sbcD | CH54_1810 | CH54_3641 | DNA polymerase family B, exonuclease domain protein; [L] COG0417 DNA polymerase elongation subunit (family B). | Exonuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.559 |
dinA | ygdG | CH54_1810 | CH54_3509 | DNA polymerase family B, exonuclease domain protein; [L] COG0417 DNA polymerase elongation subunit (family B). | Hypothetical protein; Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. | 0.901 |
dnaN | dinA | CH54_2495 | CH54_1810 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase family B, exonuclease domain protein; [L] COG0417 DNA polymerase elongation subunit (family B). | 0.989 |
dnaN | hepA | CH54_2495 | CH54_1811 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DEAD/DEAH box helicase family protein; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | 0.883 |
dnaN | mutL | CH54_2495 | CH54_2040 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA mismatch repair MutL family protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.943 |