node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
amt | glnA | CH54_3702 | CH54_2566 | Amt: ammonium transporter family protein; [P] COG0004 Ammonia permease. | glnA: glutamine synthetase, type I; [E] COG0174 Glutamine synthetase. | 0.640 |
amt | glnB | CH54_3702 | CH54_1479 | Amt: ammonium transporter family protein; [P] COG0004 Ammonia permease. | [E] COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family. | 0.998 |
amt | glnD | CH54_3702 | CH54_3518 | Amt: ammonium transporter family protein; [P] COG0004 Ammonia permease. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.537 |
amt | glnE | CH54_3702 | CH54_3113 | Amt: ammonium transporter family protein; [P] COG0004 Ammonia permease. | Glutamate-ammonia ligase adenylyltransferase family protein; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds th [...] | 0.409 |
amt | glnK | CH54_3702 | CH54_3701 | Amt: ammonium transporter family protein; [P] COG0004 Ammonia permease. | [E] COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family. | 0.999 |
amt | glnL | CH54_3702 | CH54_2565 | Amt: ammonium transporter family protein; [P] COG0004 Ammonia permease. | PAS fold family protein; [T] COG3852 Signal transduction histidine kinase, nitrogen specific. | 0.884 |
amt | gltB | CH54_3702 | CH54_3035 | Amt: ammonium transporter family protein; [P] COG0004 Ammonia permease. | Glutamine amidotransferases class-II family protein; [E] COG0070 Glutamate synthase domain 3. | 0.779 |
cobB | glnD | CH54_937 | CH54_3518 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.529 |
dapD | glnD | CH54_3517 | CH54_3518 | dapD: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; [E] COG2171 Tetrahydrodipicolinate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.725 |
dapD | map-2 | CH54_3517 | CH54_3519 | dapD: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; [E] COG2171 Tetrahydrodipicolinate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. | Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.652 |
glnA | amt | CH54_2566 | CH54_3702 | glnA: glutamine synthetase, type I; [E] COG0174 Glutamine synthetase. | Amt: ammonium transporter family protein; [P] COG0004 Ammonia permease. | 0.640 |
glnA | glnB | CH54_2566 | CH54_1479 | glnA: glutamine synthetase, type I; [E] COG0174 Glutamine synthetase. | [E] COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family. | 0.558 |
glnA | glnD | CH54_2566 | CH54_3518 | glnA: glutamine synthetase, type I; [E] COG0174 Glutamine synthetase. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.572 |
glnA | glnE | CH54_2566 | CH54_3113 | glnA: glutamine synthetase, type I; [E] COG0174 Glutamine synthetase. | Glutamate-ammonia ligase adenylyltransferase family protein; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds th [...] | 0.770 |
glnA | glnK | CH54_2566 | CH54_3701 | glnA: glutamine synthetase, type I; [E] COG0174 Glutamine synthetase. | [E] COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family. | 0.549 |
glnA | glnL | CH54_2566 | CH54_2565 | glnA: glutamine synthetase, type I; [E] COG0174 Glutamine synthetase. | PAS fold family protein; [T] COG3852 Signal transduction histidine kinase, nitrogen specific. | 0.782 |
glnA | gltB | CH54_2566 | CH54_3035 | glnA: glutamine synthetase, type I; [E] COG0174 Glutamine synthetase. | Glutamine amidotransferases class-II family protein; [E] COG0070 Glutamate synthase domain 3. | 0.991 |
glnB | amt | CH54_1479 | CH54_3702 | [E] COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family. | Amt: ammonium transporter family protein; [P] COG0004 Ammonia permease. | 0.998 |
glnB | glnA | CH54_1479 | CH54_2566 | [E] COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family. | glnA: glutamine synthetase, type I; [E] COG0174 Glutamine synthetase. | 0.558 |
glnB | glnD | CH54_1479 | CH54_3518 | [E] COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.987 |