STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CH54_3595Pyridoxal-phosphate dependent enzyme family protein; [E] COG1171 Threonine dehydratase. (322 aa)    
Predicted Functional Partners:
CH54_3596
Endoribonuclease L-PSP family protein; [J] COG0251 Putative translation initiation inhibitor, yjgF family.
 
 
 0.859
CH54_3594
Sensory box protein; [S] COG2964 Uncharacterized protein conserved in bacteria.
 
     0.813
thrA
Asp_kinase: aspartate kinase domain protein; [E] COG0460 Homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.737
metL
Asp_kinase: aspartate kinase domain protein; [E] COG0527 Aspartokinases; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.737
ilvD
ilvD: dihydroxy-acid dehydratase; [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
  
  
 0.709
edd
Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family.
  
  
 0.652
ilvN
Acolac_sm: acetolactate synthase, small subunit; [E] COG0440 Acetolactate synthase, small (regulatory) subunit.
  
  
 0.624
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.588
thrC
thrC: threonine synthase; [E] COG0498 Threonine synthase.
  
  
 0.571
CH54_391
ACT domain protein; [E] COG0440 Acetolactate synthase, small (regulatory) subunit.
  
  
 0.552
Your Current Organism:
Yersinia kristensenii
NCBI taxonomy Id: 28152
Other names: ATCC 33638, CCUG 11294, CCUG 8241, CIP 80.30, DSM 18543, JCM 7576, NCTC 11471, Y. kristensenii, strain 105
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