node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
b4390 | bioR | CH54_1860 | CH54_2863 | nadR_NMN_Atrans: nicotinamide-nucleotide adenylyltransferase; [H] COG3172 Predicted ATPase/kinase involved in NAD metabolism. | Biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.491 |
b4390 | yfcD | CH54_1860 | CH54_3908 | nadR_NMN_Atrans: nicotinamide-nucleotide adenylyltransferase; [H] COG3172 Predicted ATPase/kinase involved in NAD metabolism. | NUDIX domain protein; [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes. | 0.502 |
b4390 | yhjD | CH54_1860 | CH54_2394 | nadR_NMN_Atrans: nicotinamide-nucleotide adenylyltransferase; [H] COG3172 Predicted ATPase/kinase involved in NAD metabolism. | [S] COG1295 Predicted membrane protein. | 0.414 |
bioR | b4390 | CH54_2863 | CH54_1860 | Biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | nadR_NMN_Atrans: nicotinamide-nucleotide adenylyltransferase; [H] COG3172 Predicted ATPase/kinase involved in NAD metabolism. | 0.491 |
bioR | dapF | CH54_2863 | CH54_2776 | Biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.525 |
bioR | yfcD | CH54_2863 | CH54_3908 | Biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | NUDIX domain protein; [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes. | 0.779 |
dapF | bioR | CH54_2776 | CH54_2863 | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | Biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.525 |
dapF | yfcD | CH54_2776 | CH54_3908 | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | NUDIX domain protein; [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes. | 0.509 |
nnr | rnr | CH54_2043 | CH54_2031 | yjeF-related family protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of b [...] | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. Belongs to the RNR ribonuclease family. RNase R subfamily. | 0.425 |
nnr | yfcD | CH54_2043 | CH54_3908 | yjeF-related family protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of b [...] | NUDIX domain protein; [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes. | 0.843 |
rnr | nnr | CH54_2031 | CH54_2043 | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. Belongs to the RNR ribonuclease family. RNase R subfamily. | yjeF-related family protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of b [...] | 0.425 |
rnr | rsmA | CH54_2031 | CH54_1817 | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. Belongs to the RNR ribonuclease family. RNase R subfamily. | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.718 |
rnr | tmcA | CH54_2031 | CH54_1340 | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. Belongs to the RNR ribonuclease family. RNase R subfamily. | Acetyltransferase family protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). | 0.673 |
rnr | yfcD | CH54_2031 | CH54_3908 | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. Belongs to the RNR ribonuclease family. RNase R subfamily. | NUDIX domain protein; [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes. | 0.526 |
rof | tmcA | CH54_3543 | CH54_1340 | Hypothetical protein; Modulator of Rho-dependent transcription termination family protein; [K] COG4568 Transcriptional antiterminator. | Acetyltransferase family protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). | 0.460 |
rof | yfcD | CH54_3543 | CH54_3908 | Hypothetical protein; Modulator of Rho-dependent transcription termination family protein; [K] COG4568 Transcriptional antiterminator. | NUDIX domain protein; [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes. | 0.455 |
rof | yhjD | CH54_3543 | CH54_2394 | Hypothetical protein; Modulator of Rho-dependent transcription termination family protein; [K] COG4568 Transcriptional antiterminator. | [S] COG1295 Predicted membrane protein. | 0.510 |
rsmA | rnr | CH54_1817 | CH54_2031 | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. Belongs to the RNR ribonuclease family. RNase R subfamily. | 0.718 |
rsmA | tmcA | CH54_1817 | CH54_1340 | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | Acetyltransferase family protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). | 0.546 |
rsmA | yfcD | CH54_1817 | CH54_3908 | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | NUDIX domain protein; [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes. | 0.615 |