STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pflAPyruvate formate-lyase 1-activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (246 aa)    
Predicted Functional Partners:
pflB
Pyr_form_ly_1: formate acetyltransferase; [C] COG1882 Pyruvate-formate lyase.
  
 0.987
csdB
PFL2-3: glycyl radical enzyme, PFL2/glycerol dehydratase family protein; [C] COG1882 Pyruvate-formate lyase.
 
  
 0.944
adhE
[C] COG1012 NAD-dependent aldehyde dehydrogenases; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
 
  
 0.920
grcA
Autonomous glycyl radical cofactor GrcA; Acts as a radical domain for damaged PFL and possibly other radical proteins.
  
   
 0.775
pduQ
Iron-containing alcohol dehydrogenase family protein; [C] COG1454 Alcohol dehydrogenase, class IV.
 
  
 0.668
focA-2
formate_focA: formate transporter FocA; [P] COG2116 Formate/nitrite family of transporters.
       0.469
maeB
Malic enzyme, NAD binding domain protein; [C] COG0281 Malic enzyme.
  
  
 0.457
nrdD
nrdD: anaerobic ribonucleoside-triphosphate reductase; [F] COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase.
 
  
 0.445
pta
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
     
 0.431
Your Current Organism:
Yersinia kristensenii
NCBI taxonomy Id: 28152
Other names: ATCC 33638, CCUG 11294, CCUG 8241, CIP 80.30, DSM 18543, JCM 7576, NCTC 11471, Y. kristensenii, strain 105
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.