STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa)    
Predicted Functional Partners:
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
 0.992
pyrC
Dihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
 
 
 0.992
fre
Oxidoreductase NAD-binding domain protein; [HC] COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases.
  
 
 0.990
carB
CPSaseII_lrg: carbamoyl-phosphate synthase, large subunit; [EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family.
 
 
 0.949
carA
CPSaseIIsmall: carbamoyl-phosphate synthase, small subunit; [EF] COG0505 Carbamoylphosphate synthase small subunit; Belongs to the CarA family.
 
  
 0.944
pyrB
Asp_carb_tr: aspartate carbamoyltransferase; [F] COG0540 Aspartate carbamoyltransferase, catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
  
 0.937
pyrF
Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
  
  
 0.922
CH54_2994
Amidohydrolase family protein; [R] COG3964 Predicted amidohydrolase.
     
  0.900
pheT
pheT_bact: phenylalanine--tRNA ligase, beta subunit; [J] COG0072 Phenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
  
  
 0.895
uraA
Ncs2: uracil-xanthine permease family protein; [F] COG2233 Xanthine/uracil permeases.
  
  
 0.862
Your Current Organism:
Yersinia kristensenii
NCBI taxonomy Id: 28152
Other names: ATCC 33638, CCUG 11294, CCUG 8241, CIP 80.30, DSM 18543, JCM 7576, NCTC 11471, Y. kristensenii, strain 105
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