node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cbiC | cobB | CH54_935 | CH54_937 | precorrin-8X methylmutase family protein; [H] COG2082 Precorrin isomerase. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.998 |
cbiC | cobD | CH54_935 | CH54_936 | precorrin-8X methylmutase family protein; [H] COG2082 Precorrin isomerase. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.975 |
cbiC | cobI | CH54_935 | CH54_926 | precorrin-8X methylmutase family protein; [H] COG2082 Precorrin isomerase. | cobI_cbiL: precorrin-2 C(20)-methyltransferase; [H] COG2243 Precorrin-2 methylase; Belongs to the precorrin methyltransferase family. | 0.992 |
cbiC | cobJ | CH54_935 | CH54_929 | precorrin-8X methylmutase family protein; [H] COG2082 Precorrin isomerase. | cobJ_cbiH: precorrin-3B C17-methyltransferase; [H] COG1010 Precorrin-3B methylase. | 0.999 |
cbiC | cobO | CH54_935 | CH54_501 | precorrin-8X methylmutase family protein; [H] COG2082 Precorrin isomerase. | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.550 |
cbiC | cobQ | CH54_935 | CH54_921 | precorrin-8X methylmutase family protein; [H] COG2082 Precorrin isomerase. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.995 |
cbiC | cobS | CH54_935 | CH54_919 | precorrin-8X methylmutase family protein; [H] COG2082 Precorrin isomerase. | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.931 |
cbiC | cobT | CH54_935 | CH54_917 | precorrin-8X methylmutase family protein; [H] COG2082 Precorrin isomerase. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.900 |
cbiC | cobU | CH54_935 | CH54_920 | precorrin-8X methylmutase family protein; [H] COG2082 Precorrin isomerase. | Cobinamide kinase / cobinamide phosphate guanyltransferase family protein; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.906 |
cobB | cbiC | CH54_937 | CH54_935 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | precorrin-8X methylmutase family protein; [H] COG2082 Precorrin isomerase. | 0.998 |
cobB | cobD | CH54_937 | CH54_936 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.979 |
cobB | cobI | CH54_937 | CH54_926 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | cobI_cbiL: precorrin-2 C(20)-methyltransferase; [H] COG2243 Precorrin-2 methylase; Belongs to the precorrin methyltransferase family. | 0.952 |
cobB | cobJ | CH54_937 | CH54_929 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | cobJ_cbiH: precorrin-3B C17-methyltransferase; [H] COG1010 Precorrin-3B methylase. | 0.963 |
cobB | cobO | CH54_937 | CH54_501 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.969 |
cobB | cobQ | CH54_937 | CH54_921 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.982 |
cobB | cobS | CH54_937 | CH54_919 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.920 |
cobB | cobT | CH54_937 | CH54_917 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.976 |
cobB | cobU | CH54_937 | CH54_920 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobinamide kinase / cobinamide phosphate guanyltransferase family protein; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.977 |
cobD | cbiC | CH54_936 | CH54_935 | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | precorrin-8X methylmutase family protein; [H] COG2082 Precorrin isomerase. | 0.975 |
cobD | cobB | CH54_936 | CH54_937 | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.979 |