| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CH54_3630 | ftsN | CH54_3630 | CH54_2687 | Hypothetical protein. | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | 0.768 |
| CH54_3630 | holD | CH54_3630 | CH54_1876 | Hypothetical protein. | DNA polymerase III psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | 0.766 |
| CH54_3630 | lpoB | CH54_3630 | CH54_96 | Hypothetical protein. | Hypothetical protein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). Belongs to the LpoB family. | 0.765 |
| CH54_3630 | ompD | CH54_3630 | CH54_676 | Hypothetical protein. | [M] COG3203 Outer membrane protein (porin). | 0.748 |
| CH54_3630 | tolB | CH54_3630 | CH54_1134 | Hypothetical protein. | Tol-Pal system beta propeller repeat protein TolB; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane. | 0.535 |
| CH54_3630 | yhcB | CH54_3630 | CH54_3027 | Hypothetical protein. | Conserved hypothetical protein; [S] COG3105 Uncharacterized protein conserved in bacteria. | 0.710 |
| CH54_3630 | zapB | CH54_3630 | CH54_2682 | Hypothetical protein. | Hypothetical protein; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. | 0.683 |
| degP | ompA1 | CH54_1712 | CH54_12 | degP_htrA_DO: peptidase Do family protein; [O] COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; Belongs to the peptidase S1C family. | ompA-like transmembrane domain protein; [M] COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. | 0.760 |
| degP | ompD | CH54_1712 | CH54_676 | degP_htrA_DO: peptidase Do family protein; [O] COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; Belongs to the peptidase S1C family. | [M] COG3203 Outer membrane protein (porin). | 0.750 |
| degP | yaeT | CH54_1712 | CH54_3528 | degP_htrA_DO: peptidase Do family protein; [O] COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; Belongs to the peptidase S1C family. | Outer membrane assembly complex, YaeT protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. | 0.658 |
| ftsN | CH54_3630 | CH54_2687 | CH54_3630 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Hypothetical protein. | 0.768 |
| ftsN | holD | CH54_2687 | CH54_1876 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | DNA polymerase III psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | 0.787 |
| ftsN | lpoB | CH54_2687 | CH54_96 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Hypothetical protein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). Belongs to the LpoB family. | 0.800 |
| ftsN | ompD | CH54_2687 | CH54_676 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | [M] COG3203 Outer membrane protein (porin). | 0.757 |
| ftsN | tolB | CH54_2687 | CH54_1134 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Tol-Pal system beta propeller repeat protein TolB; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane. | 0.605 |
| ftsN | yhcB | CH54_2687 | CH54_3027 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Conserved hypothetical protein; [S] COG3105 Uncharacterized protein conserved in bacteria. | 0.742 |
| ftsN | zapB | CH54_2687 | CH54_2682 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Hypothetical protein; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. | 0.791 |
| holD | CH54_3630 | CH54_1876 | CH54_3630 | DNA polymerase III psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | Hypothetical protein. | 0.766 |
| holD | ftsN | CH54_1876 | CH54_2687 | DNA polymerase III psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | 0.787 |
| holD | lpoB | CH54_1876 | CH54_96 | DNA polymerase III psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | Hypothetical protein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). Belongs to the LpoB family. | 0.763 |