STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
putADelta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1329 aa)    
Predicted Functional Partners:
gdhA
glu/Leu/Phe/Val dehydrogenase, dimerization domain protein; [E] COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.959
proC
Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
   
 0.955
putP
Sodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
  
  
 0.954
proA
Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
    
 0.950
CH54_2491
Ornithine cyclodeaminase/mu-crystallin family protein; [E] COG2423 Predicted ornithine cyclodeaminase, mu-crystallin homolog.
  
 
 0.947
gltB
Glutamine amidotransferases class-II family protein; [E] COG0070 Glutamate synthase domain 3.
  
 
 0.946
proB
Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
    
 0.943
glnA
glnA: glutamine synthetase, type I; [E] COG0174 Glutamine synthetase.
   
 
 0.941
ybgL
lamB/YcsF family protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
   
 
  0.934
gltD_2
gltD_gamma_fam: glutamate synthase, small subunit domain protein; [ER] COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases.
     
 0.918
Your Current Organism:
Yersinia kristensenii
NCBI taxonomy Id: 28152
Other names: ATCC 33638, CCUG 11294, CCUG 8241, CIP 80.30, DSM 18543, JCM 7576, NCTC 11471, Y. kristensenii, strain 105
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