node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCO61038.1 | GDCST | VIBNI_B1277 | VIBNI_B0818 | Putative Methionine synthase II (cobalamin-independent); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Aminomethyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.532 |
CCO61038.1 | metA | VIBNI_B1277 | VIBNI_A3039 | Putative Methionine synthase II (cobalamin-independent); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | 0.542 |
CCO61038.1 | metE | VIBNI_B1277 | VIBNI_A2224 | Putative Methionine synthase II (cobalamin-independent); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.904 |
CCO61038.1 | metF | VIBNI_B1277 | VIBNI_A3598 | Putative Methionine synthase II (cobalamin-independent); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 5,10-methylenetetrahydrofolate reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the methylenetetrahydrofolate reductase family. | 0.918 |
CCO61038.1 | metH | VIBNI_B1277 | VIBNI_A3036 | Putative Methionine synthase II (cobalamin-independent); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.976 |
CCO61038.1 | thrA | VIBNI_B1277 | VIBNI_A0288 | Putative Methionine synthase II (cobalamin-independent); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Fused aspartokinase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.928 |
GDCST | CCO61038.1 | VIBNI_B0818 | VIBNI_B1277 | Aminomethyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Putative Methionine synthase II (cobalamin-independent); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.532 |
GDCST | folD | VIBNI_B0818 | VIBNI_A2454 | Aminomethyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.967 |
GDCST | glyA | VIBNI_B0818 | VIBNI_A2725 | Aminomethyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.993 |
GDCST | glyA-2 | VIBNI_B0818 | VIBNI_B0816 | Aminomethyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.991 |
GDCST | metF | VIBNI_B0818 | VIBNI_A3598 | Aminomethyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 5,10-methylenetetrahydrofolate reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the methylenetetrahydrofolate reductase family. | 0.939 |
GDCST | metH | VIBNI_B0818 | VIBNI_A3036 | Aminomethyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.957 |
GDCST | thyA | VIBNI_B0818 | VIBNI_A0338 | Aminomethyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.923 |
folD | GDCST | VIBNI_A2454 | VIBNI_B0818 | Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Aminomethyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.967 |
folD | glyA | VIBNI_A2454 | VIBNI_A2725 | Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.975 |
folD | glyA-2 | VIBNI_A2454 | VIBNI_B0816 | Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.975 |
folD | metF | VIBNI_A2454 | VIBNI_A3598 | Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 5,10-methylenetetrahydrofolate reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the methylenetetrahydrofolate reductase family. | 0.936 |
folD | metH | VIBNI_A2454 | VIBNI_A3036 | Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.525 |
folD | thyA | VIBNI_A2454 | VIBNI_A0338 | Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.942 |
glyA | GDCST | VIBNI_A2725 | VIBNI_B0818 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Aminomethyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.993 |