| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CF66_5011 | ftsH | CF66_5011 | CF66_2118 | Hypothetical protein. | ATP-dependent zinc metalloprotease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.664 |
| CF66_5011 | hflC | CF66_5011 | CF66_1008 | Hypothetical protein. | Protein HflC; HflC and HflK could regulate a protease. | 0.684 |
| CF66_5011 | hflK | CF66_5011 | CF66_1009 | Hypothetical protein. | Protein HflK; HflC and HflK could encode or regulate a protease. | 0.684 |
| dnaK | ftsH | CF66_0102 | CF66_2118 | Chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | ATP-dependent zinc metalloprotease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.417 |
| dnaK | hflC | CF66_0102 | CF66_1008 | Chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Protein HflC; HflC and HflK could regulate a protease. | 0.464 |
| dnaK | hflK | CF66_0102 | CF66_1009 | Chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Protein HflK; HflC and HflK could encode or regulate a protease. | 0.465 |
| dnaK | htpG | CF66_0102 | CF66_2170 | Chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Chaperone protein; Molecular chaperone. Has ATPase activity. | 0.990 |
| dnaK | kdkA | CF66_0102 | CF66_3047 | Chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 3-deoxy-D-manno-octulosonic acid kinase; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position; Belongs to the protein kinase superfamily. KdkA/RfaP family. | 0.688 |
| dnaK | topA | CF66_0102 | CF66_0170 | Chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.498 |
| engB | hflC | CF66_1033 | CF66_1008 | GTP-binding protein EngB; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. | Protein HflC; HflC and HflK could regulate a protease. | 0.460 |
| ftsH | CF66_5011 | CF66_2118 | CF66_5011 | ATP-dependent zinc metalloprotease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Hypothetical protein. | 0.664 |
| ftsH | dnaK | CF66_2118 | CF66_0102 | ATP-dependent zinc metalloprotease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.417 |
| ftsH | hflC | CF66_2118 | CF66_1008 | ATP-dependent zinc metalloprotease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Protein HflC; HflC and HflK could regulate a protease. | 0.979 |
| ftsH | hflK | CF66_2118 | CF66_1009 | ATP-dependent zinc metalloprotease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Protein HflK; HflC and HflK could encode or regulate a protease. | 0.986 |
| ftsH | hscA | CF66_2118 | CF66_9021 | ATP-dependent zinc metalloprotease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Chaperone protein; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. | 0.485 |
| ftsH | topA | CF66_2118 | CF66_0170 | ATP-dependent zinc metalloprotease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.636 |
| hflC | CF66_5011 | CF66_1008 | CF66_5011 | Protein HflC; HflC and HflK could regulate a protease. | Hypothetical protein. | 0.684 |
| hflC | dnaK | CF66_1008 | CF66_0102 | Protein HflC; HflC and HflK could regulate a protease. | Chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.464 |
| hflC | engB | CF66_1008 | CF66_1033 | Protein HflC; HflC and HflK could regulate a protease. | GTP-binding protein EngB; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. | 0.460 |
| hflC | ftsH | CF66_1008 | CF66_2118 | Protein HflC; HflC and HflK could regulate a protease. | ATP-dependent zinc metalloprotease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.979 |