| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CF66_7013 | birA | CF66_7013 | CF66_2125 | Dihydrofolate reductase type 3; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Bifunctional protein. | 0.753 |
| CF66_7013 | folB | CF66_7013 | CF66_2204 | Dihydrofolate reductase type 3; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.652 |
| CF66_7013 | folC | CF66_7013 | CF66_7113 | Dihydrofolate reductase type 3; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Bifunctional protein folC; Belongs to the folylpolyglutamate synthase family. | 0.986 |
| CF66_7013 | folE | CF66_7013 | CF66_2385 | Dihydrofolate reductase type 3; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | GTP cyclohydrolase 1. | 0.606 |
| CF66_7013 | folK | CF66_7013 | CF66_5006 | Dihydrofolate reductase type 3; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 0.586 |
| CF66_7013 | folP | CF66_7013 | CF66_2117 | Dihydrofolate reductase type 3; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.733 |
| CF66_7013 | ribD | CF66_7013 | CF66_4064 | Dihydrofolate reductase type 3; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Riboflavin biosynthesis protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.649 |
| birA | CF66_7013 | CF66_2125 | CF66_7013 | Bifunctional protein. | Dihydrofolate reductase type 3; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.753 |
| birA | folB | CF66_2125 | CF66_2204 | Bifunctional protein. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.764 |
| birA | folE | CF66_2125 | CF66_2385 | Bifunctional protein. | GTP cyclohydrolase 1. | 0.609 |
| birA | folK | CF66_2125 | CF66_5006 | Bifunctional protein. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 0.813 |
| birA | folP | CF66_2125 | CF66_2117 | Bifunctional protein. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.767 |
| birA | ftsH | CF66_2125 | CF66_2118 | Bifunctional protein. | ATP-dependent zinc metalloprotease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.430 |
| birA | pabC | CF66_2125 | CF66_2335 | Bifunctional protein. | Aminodeoxychorismate lyase. | 0.647 |
| birA | ribD | CF66_2125 | CF66_4064 | Bifunctional protein. | Riboflavin biosynthesis protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.757 |
| folB | CF66_7013 | CF66_2204 | CF66_7013 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydrofolate reductase type 3; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.652 |
| folB | birA | CF66_2204 | CF66_2125 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Bifunctional protein. | 0.764 |
| folB | folC | CF66_2204 | CF66_7113 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Bifunctional protein folC; Belongs to the folylpolyglutamate synthase family. | 0.868 |
| folB | folE | CF66_2204 | CF66_2385 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | GTP cyclohydrolase 1. | 0.979 |
| folB | folK | CF66_2204 | CF66_5006 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 0.998 |