clpA protein (Photodesmus katoptron) - STRING interaction network

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Score

clpA

ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. (745 aa)

Predicted Functional Partners:

clpP

0.951

dnaK

0.943

hscA

0.943

dnaL

0.835

grpE

0.797

htpG

0.668

groL1

0.614

groS

0.610

lon

0.600

rlmE

0.585

Your Current Organism:

Photodesmus katoptron

NCBI taxonomy Id: 28176
Other names: Anomalops katoptron symbiont, C. Photodesmus katoptron, Candidatus Photodesmus katoptron

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
clpA	clpP	CF66_2168	CF66_2062	ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family.	ATP-dependent Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.951
clpA	dnaK	CF66_2168	CF66_0102	ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family.	Chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.943
clpA	dnaL	CF66_2168	CF66_0103	ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family.	Chaperone protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK a [...]	0.835
clpA	groL1	CF66_2168	CF66_2083	ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family.	60 kDa chaperonin 1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.614
clpA	groS	CF66_2168	CF66_2082	ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family.	10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.610
clpA	grpE	CF66_2168	CF66_0101	ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family.	Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...]	0.797
clpA	hscA	CF66_2168	CF66_9021	ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family.	Chaperone protein; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.	0.943
clpA	htpG	CF66_2168	CF66_2170	ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family.	Chaperone protein; Molecular chaperone. Has ATPase activity.	0.668
clpA	lon	CF66_2168	CF66_2347	ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family.	Protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.	0.600
clpA	rlmE	CF66_2168	CF66_2119	ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family.	Ribosomal RNA large subunit methyltransferase E; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.	0.585
clpP	clpA	CF66_2062	CF66_2168	ATP-dependent Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family.	0.951
clpP	dnaK	CF66_2062	CF66_0102	ATP-dependent Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.618
clpP	dnaL	CF66_2062	CF66_0103	ATP-dependent Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Chaperone protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK a [...]	0.651
clpP	groL1	CF66_2062	CF66_2083	ATP-dependent Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	60 kDa chaperonin 1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.722
clpP	groS	CF66_2062	CF66_2082	ATP-dependent Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.769
clpP	grpE	CF66_2062	CF66_0101	ATP-dependent Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...]	0.774
clpP	hscA	CF66_2062	CF66_9021	ATP-dependent Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Chaperone protein; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.	0.602
clpP	htpG	CF66_2062	CF66_2170	ATP-dependent Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Chaperone protein; Molecular chaperone. Has ATPase activity.	0.534
clpP	lon	CF66_2062	CF66_2347	ATP-dependent Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.	0.716
dnaK	clpA	CF66_0102	CF66_2168	Chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family.	ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family.	0.943