| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cmk | guaB | CF66_2350 | CF66_9009 | Cytidylate kinase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.596 |
| cmk | ppiD | CF66_2350 | CF66_2349 | Cytidylate kinase. | Peptidyl-prolyl cis-trans isomerase D. | 0.611 |
| cmk | tig | CF66_2350 | CF66_2344 | Cytidylate kinase. | Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. | 0.439 |
| flgG | ppiD | CF66_4035 | CF66_2349 | Flagellar basal-body rod protein flgG; Belongs to the flagella basal body rod proteins family. | Peptidyl-prolyl cis-trans isomerase D. | 0.543 |
| flgG | surA | CF66_4035 | CF66_7008 | Flagellar basal-body rod protein flgG; Belongs to the flagella basal body rod proteins family. | Chaperone surA; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. | 0.543 |
| guaB | cmk | CF66_9009 | CF66_2350 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Cytidylate kinase. | 0.596 |
| guaB | kdkA | CF66_9009 | CF66_3047 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 3-deoxy-D-manno-octulosonic acid kinase; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position; Belongs to the protein kinase superfamily. KdkA/RfaP family. | 0.785 |
| guaB | ppiD | CF66_9009 | CF66_2349 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Peptidyl-prolyl cis-trans isomerase D. | 0.540 |
| guaB | surA | CF66_9009 | CF66_7008 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Chaperone surA; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. | 0.541 |
| guaB | tig | CF66_9009 | CF66_2344 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. | 0.535 |
| iptD | ppiD | CF66_7006 | CF66_2349 | LPS-assembly protein lptD; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. | Peptidyl-prolyl cis-trans isomerase D. | 0.691 |
| iptD | surA | CF66_7006 | CF66_7008 | LPS-assembly protein lptD; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. | Chaperone surA; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. | 0.821 |
| iptD | yaeT | CF66_7006 | CF66_2011 | LPS-assembly protein lptD; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. | Outer membrane protein assembly factor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | 0.706 |
| kdkA | guaB | CF66_3047 | CF66_9009 | 3-deoxy-D-manno-octulosonic acid kinase; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position; Belongs to the protein kinase superfamily. KdkA/RfaP family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.785 |
| kdkA | ppiD | CF66_3047 | CF66_2349 | 3-deoxy-D-manno-octulosonic acid kinase; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position; Belongs to the protein kinase superfamily. KdkA/RfaP family. | Peptidyl-prolyl cis-trans isomerase D. | 0.550 |
| kdkA | surA | CF66_3047 | CF66_7008 | 3-deoxy-D-manno-octulosonic acid kinase; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position; Belongs to the protein kinase superfamily. KdkA/RfaP family. | Chaperone surA; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. | 0.444 |
| nfuA | ppiD | CF66_6021 | CF66_2349 | Fe/S biogenesis protein nfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | Peptidyl-prolyl cis-trans isomerase D. | 0.504 |
| nfuA | surA | CF66_6021 | CF66_7008 | Fe/S biogenesis protein nfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | Chaperone surA; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. | 0.504 |
| ppiD | cmk | CF66_2349 | CF66_2350 | Peptidyl-prolyl cis-trans isomerase D. | Cytidylate kinase. | 0.611 |
| ppiD | flgG | CF66_2349 | CF66_4035 | Peptidyl-prolyl cis-trans isomerase D. | Flagellar basal-body rod protein flgG; Belongs to the flagella basal body rod proteins family. | 0.543 |