| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CF66_2302 | CF66_3063 | CF66_2302 | CF66_3063 | Esterase/lipase. | Hypothetical protein. | 0.577 |
| CF66_2302 | guaA | CF66_2302 | CF66_9008 | Esterase/lipase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.769 |
| CF66_2302 | guaB | CF66_2302 | CF66_9009 | Esterase/lipase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.766 |
| CF66_3063 | CF66_2302 | CF66_3063 | CF66_2302 | Hypothetical protein. | Esterase/lipase. | 0.577 |
| CF66_3063 | fre | CF66_3063 | CF66_3036 | Hypothetical protein. | NAD(P)H-flavin reductase. | 0.531 |
| CF66_3063 | glyA | CF66_3063 | CF66_0117 | Hypothetical protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.498 |
| CF66_3063 | guaA | CF66_3063 | CF66_9008 | Hypothetical protein. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.777 |
| CF66_3063 | guaB | CF66_3063 | CF66_9009 | Hypothetical protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.829 |
| CF66_3063 | luxG | CF66_3063 | CF66_3017 | Hypothetical protein. | Flavin reductase luxG. | 0.521 |
| CF66_3063 | ribD | CF66_3063 | CF66_4064 | Hypothetical protein. | Riboflavin biosynthesis protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.979 |
| CF66_3063 | ribE | CF66_3063 | CF66_0168 | Hypothetical protein. | Riboflavin synthase alpha chain. | 0.938 |
| CF66_3063 | ribF | CF66_3063 | CF66_9057 | Hypothetical protein. | Riboflavin biosynthesis protein ribF; Belongs to the ribF family. | 0.943 |
| CF66_3063 | ribH | CF66_3063 | CF66_4066 | Hypothetical protein. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.967 |
| fre | CF66_3063 | CF66_3036 | CF66_3063 | NAD(P)H-flavin reductase. | Hypothetical protein. | 0.531 |
| fre | ribE | CF66_3036 | CF66_0168 | NAD(P)H-flavin reductase. | Riboflavin synthase alpha chain. | 0.449 |
| fre | ribF | CF66_3036 | CF66_9057 | NAD(P)H-flavin reductase. | Riboflavin biosynthesis protein ribF; Belongs to the ribF family. | 0.467 |
| glyA | CF66_3063 | CF66_0117 | CF66_3063 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Hypothetical protein. | 0.498 |
| glyA | guaA | CF66_0117 | CF66_9008 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.829 |
| glyA | guaB | CF66_0117 | CF66_9009 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.891 |
| glyA | ribD | CF66_0117 | CF66_4064 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Riboflavin biosynthesis protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.430 |