| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ispA | ispB | CF66_0108 | CF66_7017 | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.972 |
| ispA | ispH | CF66_0108 | CF66_9054 | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.956 |
| ispA | luxD | CF66_0108 | CF66_3021 | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Acyl transferase luxD. | 0.647 |
| ispA | ubiA | CF66_0108 | CF66_3054 | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.495 |
| ispA | ubiE | CF66_0108 | CF66_1021 | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Ubiquinone/menaquinone biosynthesis methyltransferase ubiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.650 |
| ispA | uppS | CF66_0108 | CF66_2007 | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Undecaprenyl pyrophosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.981 |
| ispB | ispA | CF66_7017 | CF66_0108 | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.972 |
| ispB | ispH | CF66_7017 | CF66_9054 | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.512 |
| ispB | lolA | CF66_7017 | CF66_2358 | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Outer-membrane lipoprotein carrier protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). | 0.583 |
| ispB | luxD | CF66_7017 | CF66_3021 | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Acyl transferase luxD. | 0.647 |
| ispB | rplU | CF66_7017 | CF66_7016 | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.538 |
| ispB | rpmA | CF66_7017 | CF66_7015 | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 50S ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. | 0.513 |
| ispB | rpsA | CF66_7017 | CF66_2351 | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 30S ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. | 0.472 |
| ispB | ubiA | CF66_7017 | CF66_3054 | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.963 |
| ispB | ubiE | CF66_7017 | CF66_1021 | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Ubiquinone/menaquinone biosynthesis methyltransferase ubiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.775 |
| ispB | uppS | CF66_7017 | CF66_2007 | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Undecaprenyl pyrophosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.986 |
| ispH | ispA | CF66_9054 | CF66_0108 | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.956 |
| ispH | ispB | CF66_9054 | CF66_7017 | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.512 |
| ispH | luxD | CF66_9054 | CF66_3021 | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | Acyl transferase luxD. | 0.607 |
| ispH | rpsA | CF66_9054 | CF66_2351 | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 30S ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. | 0.946 |