| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| guaA | guaB | CF66_9008 | CF66_9009 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
| guaA | kdsD | CF66_9008 | CF66_7039 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Arabinose 5-phosphate isomerase. | 0.919 |
| guaA | pfkA | CF66_9008 | CF66_3005 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | 0.975 |
| guaA | pgi | CF66_9008 | CF66_4011 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Glucose-6-phosphate isomerase; Belongs to the GPI family. | 0.635 |
| guaA | rpe | CF66_9008 | CF66_2152 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | 0.609 |
| guaB | guaA | CF66_9009 | CF66_9008 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.999 |
| guaB | kdsA | CF66_9009 | CF66_3064 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. | 0.671 |
| guaB | kdsD | CF66_9009 | CF66_7039 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Arabinose 5-phosphate isomerase. | 0.912 |
| guaB | pfkA | CF66_9009 | CF66_3005 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | 0.460 |
| guaB | pgi | CF66_9009 | CF66_4011 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Glucose-6-phosphate isomerase; Belongs to the GPI family. | 0.667 |
| guaB | rpe | CF66_9009 | CF66_2152 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | 0.595 |
| kdsA | guaB | CF66_3064 | CF66_9009 | 2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.671 |
| kdsA | kdsB | CF66_3064 | CF66_2160 | 2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.909 |
| kdsA | kdsC | CF66_3064 | CF66_7040 | 2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. | 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. | 0.960 |
| kdsA | kdsD | CF66_3064 | CF66_7039 | 2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. | Arabinose 5-phosphate isomerase. | 0.975 |
| kdsB | kdsA | CF66_2160 | CF66_3064 | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. | 0.909 |
| kdsB | kdsC | CF66_2160 | CF66_7040 | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. | 0.887 |
| kdsB | kdsD | CF66_2160 | CF66_7039 | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | Arabinose 5-phosphate isomerase. | 0.902 |
| kdsC | kdsA | CF66_7040 | CF66_3064 | 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. | 2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. | 0.960 |
| kdsC | kdsB | CF66_7040 | CF66_2160 | 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.887 |