STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (342 aa)    
Predicted Functional Partners:
CEN37460.1
Pre-uroporphyrinogen synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.985
hemD
Uroporphyrinogen III synthase HEM4.
 
 
 0.947
HemN
Coproporphyrinogen-III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family.
 
 
 0.937
CEN33758.1
Uroporphyrinogen-III synthase.
  
 
 0.917
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.807
hemB
Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.779
hemA
Glutamyl-tRNA reductase 1; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.670
tpiA
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
  
  
 0.645
hemL
Glutamate-1-semialdehyde aminotransferase (aminomutase); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
  
 0.600
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.595
Your Current Organism:
Capnocytophaga cynodegmi
NCBI taxonomy Id: 28189
Other names: ATCC 49044, C. cynodegmi, CCUG 24742, CDC group DF-2 like, CIP 103937, DSM 19736, LMG 11513, LMG:11513, NCTC 12243, strain E6447
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.