node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DF188_00805 | DF188_01740 | GCA_001572935_00631 | GCA_001572935_00835 | Unannotated protein; Belongs to the AdoMet synthase family. | Unannotated protein; Belongs to the methylenetetrahydrofolate reductase family. | 0.757 |
DF188_00805 | glyA | GCA_001572935_00631 | GCA_001572935_00098 | Unannotated protein; Belongs to the AdoMet synthase family. | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.475 |
DF188_00805 | metE | GCA_001572935_00631 | GCA_001572935_00766 | Unannotated protein; Belongs to the AdoMet synthase family. | Unannotated protein; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.979 |
DF188_00805 | metH | GCA_001572935_00631 | GCA_001572935_01654 | Unannotated protein; Belongs to the AdoMet synthase family. | Unannotated protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.968 |
DF188_01740 | DF188_00805 | GCA_001572935_00835 | GCA_001572935_00631 | Unannotated protein; Belongs to the methylenetetrahydrofolate reductase family. | Unannotated protein; Belongs to the AdoMet synthase family. | 0.757 |
DF188_01740 | DF188_06990 | GCA_001572935_00835 | GCA_001572935_01388 | Unannotated protein; Belongs to the methylenetetrahydrofolate reductase family. | Unannotated protein. | 0.693 |
DF188_01740 | DF188_06995 | GCA_001572935_00835 | GCA_001572935_01389 | Unannotated protein; Belongs to the methylenetetrahydrofolate reductase family. | Unannotated protein. | 0.693 |
DF188_01740 | DF188_09830 | GCA_001572935_00835 | GCA_001572935_01766 | Unannotated protein; Belongs to the methylenetetrahydrofolate reductase family. | Unannotated protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.905 |
DF188_01740 | RuvX | GCA_001572935_00835 | GCA_001572935_00836 | Unannotated protein; Belongs to the methylenetetrahydrofolate reductase family. | Unannotated protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | 0.800 |
DF188_01740 | folD | GCA_001572935_00835 | GCA_001572935_01408 | Unannotated protein; Belongs to the methylenetetrahydrofolate reductase family. | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.940 |
DF188_01740 | gltS | GCA_001572935_00835 | GCA_001572935_00837 | Unannotated protein; Belongs to the methylenetetrahydrofolate reductase family. | Unannotated protein; Catalyzes the sodium-dependent transport of glutamate. Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family. | 0.695 |
DF188_01740 | glyA | GCA_001572935_00835 | GCA_001572935_00098 | Unannotated protein; Belongs to the methylenetetrahydrofolate reductase family. | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.919 |
DF188_01740 | metE | GCA_001572935_00835 | GCA_001572935_00766 | Unannotated protein; Belongs to the methylenetetrahydrofolate reductase family. | Unannotated protein; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.932 |
DF188_01740 | metH | GCA_001572935_00835 | GCA_001572935_01654 | Unannotated protein; Belongs to the methylenetetrahydrofolate reductase family. | Unannotated protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.998 |
DF188_06990 | DF188_01740 | GCA_001572935_01388 | GCA_001572935_00835 | Unannotated protein. | Unannotated protein; Belongs to the methylenetetrahydrofolate reductase family. | 0.693 |
DF188_06990 | DF188_06995 | GCA_001572935_01388 | GCA_001572935_01389 | Unannotated protein. | Unannotated protein. | 0.983 |
DF188_06990 | metE | GCA_001572935_01388 | GCA_001572935_00766 | Unannotated protein. | Unannotated protein; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.964 |
DF188_06990 | metH | GCA_001572935_01388 | GCA_001572935_01654 | Unannotated protein. | Unannotated protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.976 |
DF188_06995 | DF188_01740 | GCA_001572935_01389 | GCA_001572935_00835 | Unannotated protein. | Unannotated protein; Belongs to the methylenetetrahydrofolate reductase family. | 0.693 |
DF188_06995 | DF188_06990 | GCA_001572935_01389 | GCA_001572935_01388 | Unannotated protein. | Unannotated protein. | 0.983 |