A0A1I8I0G7 protein (Macrostomum lignano) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

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A0A1I8I0G7

Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family. (193 aa)

Predicted Functional Partners:

A0A267EAE9

0.648

A0A267EH89

0.648

A0A267F413

0.648

A0A267DHW1

0.638

A0A267E7E7

0.638

A0A267FD94

0.638

A0A267FFC7

0.585

A0A267GK13

0.585

A0A267GBQ9

0.570

A0A267DZE8

0.475

Your Current Organism:

Macrostomum lignano

NCBI taxonomy Id: 282301
Other names: M. lignano

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1I8I0G7	A0A267DHW1	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	Uncharacterized protein; Belongs to the ferrochelatase family.	0.638
A0A1I8I0G7	A0A267DZE8	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	BZIP domain-containing protein.	0.475
A0A1I8I0G7	A0A267E7E7	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.	0.638
A0A1I8I0G7	A0A267EAE9	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	Uncharacterized protein.	0.648
A0A1I8I0G7	A0A267EH89	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	Uncharacterized protein.	0.648
A0A1I8I0G7	A0A267F413	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	Uncharacterized protein.	0.648
A0A1I8I0G7	A0A267FD94	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.	0.638
A0A1I8I0G7	A0A267FFC7	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	ARA70 domain-containing protein.	0.585
A0A1I8I0G7	A0A267GBQ9	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	Uncharacterized protein.	0.570
A0A1I8I0G7	A0A267GK13	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	ARA70 domain-containing protein.	0.585
A0A267DHW1	A0A1I8I0G7	Uncharacterized protein; Belongs to the ferrochelatase family.	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	0.638
A0A267DZE8	A0A1I8I0G7	BZIP domain-containing protein.	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	0.475
A0A267E7E7	A0A1I8I0G7	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	0.638
A0A267EAE9	A0A1I8I0G7	Uncharacterized protein.	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	0.648
A0A267EAE9	A0A267EH89	Uncharacterized protein.	Uncharacterized protein.	0.987
A0A267EAE9	A0A267F413	Uncharacterized protein.	Uncharacterized protein.	0.988
A0A267EAE9	A0A267GBQ9	Uncharacterized protein.	Uncharacterized protein.	0.717
A0A267EH89	A0A1I8I0G7	Uncharacterized protein.	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	0.648
A0A267EH89	A0A267EAE9	Uncharacterized protein.	Uncharacterized protein.	0.987
A0A267EH89	A0A267F413	Uncharacterized protein.	Uncharacterized protein.	0.988

page 1 of 2

Network Stats

number of nodes:

7

number of edges:

21

average node degree:

6

avg. local clustering coefficient:

1

expected number of edges:

8

PPI enrichment p-value:

3.49e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000162

Tryptophan biosynthetic process

5 of 5

2.58

4.14

1.23e-08

GO:0008652

Cellular amino acid biosynthetic process

6 of 98

1.37

1.67

6.86e-06

GO:0019752

Carboxylic acid metabolic process

7 of 329

0.91

0.81

0.00030

GO:0009058

Biosynthetic process

9 of 752

0.66

0.55

0.00040

GO:0044249

Cellular biosynthetic process

8 of 696

0.64

0.49

0.0028

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004834

Tryptophan synthase activity

2 of 2

2.58

1.05

0.0124

GO:0016829

Lyase activity

5 of 119

1.21

0.87

0.0054

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:888

Aromatic amino acid biosynthesis, and ADC synthase

9 of 15

2.36

7.42

3.94e-17

CL:886

Phenylalanine, tyrosine and tryptophan biosynthesis, and Histidine biosynthetic process

10 of 33

2.06

6.26

3.94e-17

CL:891

Tryptophan biosynthesis

5 of 5

2.58

4.63

1.20e-09

CL:884

Biosynthesis of amino acids

11 of 94

1.65

4.06

3.06e-16

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00400

Phenylalanine, tyrosine and tryptophan biosynthesis

8 of 25

2.09

5.37

1.14e-13

map01230

Biosynthesis of amino acids

10 of 131

1.47

2.86

8.46e-13

map01110

Biosynthesis of secondary metabolites

10 of 509

0.88

0.95

3.00e-07

map00260

Glycine, serine and threonine metabolism

3 of 45

1.41

0.95

0.0068

map01100

Metabolic pathways

10 of 1538

0.4

0.31

0.0080

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0822

Tryptophan biosynthesis

5 of 5

2.58

4.5

2.14e-09

KW-0028

Amino-acid biosynthesis

6 of 57

1.61

2.39

2.59e-07

KW-0456

Lyase

3 of 71

1.21

0.61

0.0398

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04715

Anthranilate synthase component I, N terminal region

2 of 2

2.58

0.91

0.0224

PF00425

Chorismate binding enzyme

2 of 2

2.58

0.91

0.0224

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR011060

Ribulose-phosphate binding barrel

4 of 7

2.34

2.55

1.25e-05

IPR013785

Aldolase-type TIM barrel

5 of 48

1.6

1.7

8.60e-05

IPR019999

Anthranilate synthase component I-like

2 of 2

2.58

0.95

0.0189

IPR015890

Chorismate-utilising enzyme, C-terminal

2 of 2

2.58

0.95

0.0189

IPR005801

ADC synthase

2 of 2

2.58

0.95

0.0189

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