A0A267E5Y6 protein (Macrostomum lignano) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A267E5Y6

Myb-like domain-containing protein. (1650 aa)

Predicted Functional Partners:

A0A267E8A3

0.780

A0A267EYR0

0.780

A0A267EYT1

0.780

A0A267FM03

0.780

A0A267G489

0.780

A0A267EIS7

0.764

A0A267FJT4

0.764

A0A267G1B6

0.764

A0A267G5Q1

0.736

A0A1I8G0H1

0.725

Your Current Organism:

Macrostomum lignano

NCBI taxonomy Id: 282301
Other names: M. lignano

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1I8G0H1	A0A267E5Y6	ERCC4 domain-containing protein.	Myb-like domain-containing protein.	0.725
A0A1I8G0H1	A0A267EIS7	ERCC4 domain-containing protein.	Uncharacterized protein.	0.995
A0A1I8G0H1	A0A267EYR0	ERCC4 domain-containing protein.	DNA polymerase.	0.800
A0A1I8G0H1	A0A267EYT1	ERCC4 domain-containing protein.	DNA polymerase.	0.800
A0A1I8G0H1	A0A267FJT4	ERCC4 domain-containing protein.	Uncharacterized protein.	0.995
A0A1I8G0H1	A0A267G1B6	ERCC4 domain-containing protein.	Uncharacterized protein.	0.995
A0A267E5Y6	A0A1I8G0H1	Myb-like domain-containing protein.	ERCC4 domain-containing protein.	0.725
A0A267E5Y6	A0A267E8A3	Myb-like domain-containing protein.	Uncharacterized protein.	0.780
A0A267E5Y6	A0A267EIS7	Myb-like domain-containing protein.	Uncharacterized protein.	0.764
A0A267E5Y6	A0A267EYR0	Myb-like domain-containing protein.	DNA polymerase.	0.780
A0A267E5Y6	A0A267EYT1	Myb-like domain-containing protein.	DNA polymerase.	0.780
A0A267E5Y6	A0A267FJT4	Myb-like domain-containing protein.	Uncharacterized protein.	0.764
A0A267E5Y6	A0A267FM03	Myb-like domain-containing protein.	Uncharacterized protein.	0.780
A0A267E5Y6	A0A267G1B6	Myb-like domain-containing protein.	Uncharacterized protein.	0.764
A0A267E5Y6	A0A267G489	Myb-like domain-containing protein.	Uncharacterized protein.	0.780
A0A267E5Y6	A0A267G5Q1	Myb-like domain-containing protein.	Small nuclear ribonucleoprotein Sm D2.	0.736
A0A267E8A3	A0A267E5Y6	Uncharacterized protein.	Myb-like domain-containing protein.	0.780
A0A267E8A3	A0A267EYR0	Uncharacterized protein.	DNA polymerase.	0.479
A0A267E8A3	A0A267EYT1	Uncharacterized protein.	DNA polymerase.	0.479
A0A267E8A3	A0A267FM03	Uncharacterized protein.	Uncharacterized protein.	0.994

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.896

expected number of edges:

14

PPI enrichment p-value:

0.0178

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0060271

Cilium assembly

10 of 282

1.91

5.12

3.08e-15

GO:1905515

Non-motile cilium assembly

5 of 44

2.42

4.06

1.02e-08

GO:0007224

Smoothened signaling pathway

5 of 60

2.28

3.67

3.90e-08

GO:1904491

Protein localization to ciliary transition zone

3 of 6

3.06

3.0

3.47e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0036038

MKS complex

10 of 11

3.32

14.87

1.59e-28

GO:0060170

Ciliary membrane

4 of 50

2.27

2.98

1.26e-06

GO:0036064

Ciliary basal body

3 of 134

1.71

1.19

0.0035

GO:0005813

Centrosome

4 of 433

1.33

1.0

0.0035

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:23870701

(2013) Joubert syndrome: congenital cerebellar ataxia with the molar tooth.

6 of 25

2.74

5.34

7.18e-11

PMID:26673778

(2016) Large-scale targeted sequencing comparison highlights extreme genetic heterogeneity in nephronophthisis-related ciliopathies.

6 of 28

2.69

5.31

7.18e-11

PMID:25729630

(2014) Unraveling the genetics of Joubert and Meckel-Gruber syndromes.

6 of 30

2.66

5.28

7.18e-11

PMID:28401750

(2017) The Ciliary Transition Zone: Finding the Pieces and Assembling the Gate.

6 of 35

2.6

5.14

1.09e-10

PMID:23352055

(2012) The transition zone: an essential functional compartment of cilia.

6 of 37

2.57

5.1

1.19e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15866

Mixed, incl. Intraciliary transport particle, and Ciliary transition zone

11 of 76

2.52

10.72

2.14e-24

CL:15875

Mixed, incl. MKS complex, and Pronephros formation

8 of 20

2.97

9.88

1.29e-19

CL:15878

MKS complex, and Protein localization to ciliary transition zone

6 of 14

3.0

7.26

2.60e-14

CL:15880

MKS complex, and Predicted membrane protein

5 of 8

3.16

6.24

3.33e-12

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

DRE-5620912

Anchoring of the basal body to the plasma membrane

4 of 83

2.05

2.07

6.69e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0036038

MKS complex

11 of 14

3.26

16.39

9.85e-32

GOCC:0060170

Ciliary membrane

3 of 42

2.22

1.93

0.00019

GOCC:0036064

Ciliary basal body

2 of 53

1.94

0.74

0.0394

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0970

Cilium biogenesis/degradation

6 of 55

2.4

5.18

2.81e-11

KW-0969

Cilium

4 of 64

2.16

2.81

2.10e-06

KW-0966

Cell projection

5 of 160

1.86

2.63

1.01e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07162

Ciliary basal body-associated, B9 protein

3 of 3

3.36

3.07

2.90e-06

PF14995

Transmembrane protein

2 of 2

3.36

1.62

0.0012

PF09799

Predicted membrane protein

2 of 3

3.19

1.58

0.0014

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR010796

B9-type C2 domain

3 of 3

3.36

2.87

6.69e-06

IPR029248

Transmembrane protein 107

2 of 2

3.36

1.42

0.0028

IPR019184

Uncharacterised protein family, transmembrane-17

2 of 3

3.19

1.39

0.0031

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About