A0A267EGR5 protein (Macrostomum lignano) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

A0A267EGR5

XPA_C domain-containing protein. (280 aa)

Predicted Functional Partners:

A0A267DH29

0.993

A0A267EIS7

0.987

A0A267FJT4

0.987

A0A267G1B6

0.987

A0A267E526

0.982

A0A267FW88

0.982

A0A267F3H4

0.981

A0A267G5F8

0.981

A0A267H481

0.981

A0A267DMJ4

0.978

Your Current Organism:

Macrostomum lignano

NCBI taxonomy Id: 282301
Other names: M. lignano

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A267DH29	A0A267DMJ4	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.856
A0A267DH29	A0A267E526	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.996
A0A267DH29	A0A267EGR5	Helicase ATP-binding domain-containing protein.	XPA_C domain-containing protein.	0.993
A0A267DH29	A0A267EIS7	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.868
A0A267DH29	A0A267F3H4	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.892
A0A267DH29	A0A267FJT4	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.868
A0A267DH29	A0A267FW88	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.996
A0A267DH29	A0A267G1B6	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.868
A0A267DH29	A0A267G5F8	Helicase ATP-binding domain-containing protein.	ERCC4 domain-containing protein.	0.892
A0A267DH29	A0A267H481	Helicase ATP-binding domain-containing protein.	ERCC4 domain-containing protein.	0.892
A0A267DMJ4	A0A267DH29	Uncharacterized protein.	Helicase ATP-binding domain-containing protein.	0.856
A0A267DMJ4	A0A267E526	Uncharacterized protein.	Uncharacterized protein.	0.821
A0A267DMJ4	A0A267EGR5	Uncharacterized protein.	XPA_C domain-containing protein.	0.978
A0A267DMJ4	A0A267EIS7	Uncharacterized protein.	Uncharacterized protein.	0.998
A0A267DMJ4	A0A267F3H4	Uncharacterized protein.	Uncharacterized protein.	0.988
A0A267DMJ4	A0A267FJT4	Uncharacterized protein.	Uncharacterized protein.	0.998
A0A267DMJ4	A0A267FW88	Uncharacterized protein.	Uncharacterized protein.	0.821
A0A267DMJ4	A0A267G1B6	Uncharacterized protein.	Uncharacterized protein.	0.998
A0A267DMJ4	A0A267G5F8	Uncharacterized protein.	ERCC4 domain-containing protein.	0.988
A0A267DMJ4	A0A267H481	Uncharacterized protein.	ERCC4 domain-containing protein.	0.988

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.958

expected number of edges:

14

PPI enrichment p-value:

1.12e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042073

Intraciliary transport

5 of 24

2.5

4.01

1.70e-08

GO:0060271

Cilium assembly

6 of 114

1.9

3.09

6.86e-08

GO:0007017

Microtubule-based process

6 of 255

1.55

2.12

1.54e-06

GO:0048736

Appendage development

2 of 7

2.64

1.46

0.0021

GO:0048513

Animal organ development

3 of 66

1.84

1.37

0.0017

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030992

Intraciliary transport particle B

7 of 16

2.82

7.82

8.84e-16

GO:0036064

Ciliary basal body

6 of 41

2.35

5.02

4.29e-11

GO:0005929

Cilium

7 of 186

1.76

3.27

1.54e-09

GO:0005813

Centrosome

5 of 77

1.99

3.15

1.13e-07

GO:0005814

Centriole

3 of 31

2.17

2.07

9.08e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1366

Intraciliary transport particle B

7 of 13

2.91

7.99

6.53e-16

CL:1337

Intraciliary transport particle, and Ankyrin repeat

8 of 52

2.37

6.8

2.02e-15

CL:1368

Intraciliary transport particle B

3 of 5

2.96

3.19

1.47e-06

CL:11887

Mixed, incl. Glycerophosphodiester phosphodiesterase domain, and SPX domain

2 of 6

2.7

1.58

0.0013

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5620924

Intraflagellar transport

7 of 33

2.51

6.45

7.96e-14

MAP-5617833

Cilium Assembly

7 of 111

1.98

4.15

1.11e-10

MAP-1852241

Organelle biogenesis and maintenance

7 of 130

1.91

3.89

2.14e-10

MAP-5610787

Hedgehog off state

4 of 48

2.1

2.56

6.38e-06

MAP-5358351

Signaling by Hedgehog

4 of 100

1.78

1.86

8.52e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03009

Glycerophosphoryl diester phosphodiesterase family

2 of 6

2.7

1.04

0.0132

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030395

Glycerophosphodiester phosphodiesterase domain

2 of 6

2.7

0.81

0.0348

IPR017946

PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily

2 of 8

2.58

0.8

0.0348

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