A0A267EX88 protein (Macrostomum lignano) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

A0A267EX88

AB hydrolase-1 domain-containing protein. (462 aa)

Predicted Functional Partners:

A0A267FX19

0.908

A0A267FYY8

0.908

A0A267G854

0.908

A0A267E467

0.897

A0A267FJ37

0.897

A0A267G117

0.897

A0A267FGU1

0.896

A0A267FIF3

0.896

A0A267FTM0

0.896

A0A267FVY1

0.896

Your Current Organism:

Macrostomum lignano

NCBI taxonomy Id: 282301
Other names: M. lignano

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A267E467	A0A267EX88	Uncharacterized protein.	AB hydrolase-1 domain-containing protein.	0.897
A0A267E467	A0A267FJ37	Uncharacterized protein.	Uncharacterized protein.	0.933
A0A267E467	A0A267G117	Uncharacterized protein.	Uncharacterized protein.	0.933
A0A267EX88	A0A267E467	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.897
A0A267EX88	A0A267FGU1	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.896
A0A267EX88	A0A267FIF3	AB hydrolase-1 domain-containing protein.	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	0.896
A0A267EX88	A0A267FJ37	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.897
A0A267EX88	A0A267FTM0	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.896
A0A267EX88	A0A267FVY1	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.896
A0A267EX88	A0A267FX19	AB hydrolase-1 domain-containing protein.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.908
A0A267EX88	A0A267FYY8	AB hydrolase-1 domain-containing protein.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.908
A0A267EX88	A0A267G117	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.897
A0A267EX88	A0A267G854	AB hydrolase-1 domain-containing protein.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.908
A0A267FGU1	A0A267EX88	Uncharacterized protein.	AB hydrolase-1 domain-containing protein.	0.896
A0A267FGU1	A0A267FIF3	Uncharacterized protein.	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	0.999
A0A267FGU1	A0A267FTM0	Uncharacterized protein.	Uncharacterized protein.	0.999
A0A267FGU1	A0A267FVY1	Uncharacterized protein.	Uncharacterized protein.	0.999
A0A267FGU1	A0A267FX19	Uncharacterized protein.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.731
A0A267FGU1	A0A267FYY8	Uncharacterized protein.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.731
A0A267FGU1	A0A267G854	Uncharacterized protein.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.731

page 1 of 4

Network Stats

number of nodes:

4

number of edges:

3

average node degree:

1.5

avg. local clustering coefficient:

0.75

expected number of edges:

3

PPI enrichment p-value:

0.562

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1903778

Protein localization to vacuolar membrane

2 of 3

3.29

1.64

0.0011

GO:0010994

Free ubiquitin chain polymerization

2 of 4

3.16

1.64

0.0011

GO:0008283

Cell population proliferation

2 of 4

3.16

1.64

0.0011

GO:0070534

Protein K63-linked ubiquitination

2 of 6

2.99

1.63

0.0011

GO:2001234

Negative regulation of apoptotic signaling pathway

2 of 8

2.86

1.61

0.0012

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061631

Ubiquitin conjugating enzyme activity

4 of 24

2.68

3.52

2.61e-07

GO:0004842

Ubiquitin-protein transferase activity

5 of 177

1.91

2.64

1.43e-06

GO:0004869

Cysteine-type endopeptidase inhibitor activity

2 of 4

3.16

1.81

0.00054

GO:0140096

Catalytic activity, acting on a protein

6 of 1625

1.03

0.83

0.0018

GO:0016740

Transferase activity

6 of 1899

0.96

0.74

0.0031

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031371

Ubiquitin conjugating enzyme complex

2 of 5

3.06

1.53

0.0017

GO:0005819

Spindle

3 of 73

2.08

1.44

0.0017

GO:0000922

Spindle pole

2 of 14

2.62

1.34

0.0035

GO:0030496

Midbody

2 of 26

2.35

1.13

0.0083

GO:0005802

trans-Golgi network

2 of 28

2.32

1.12

0.0083

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3111

IRAK2 mediated activation of TAK1 complex, and Ubiquitin conjugating enzyme activity

4 of 14

2.92

3.87

7.40e-08

CL:3091

Mixed, incl. Ubiquitin conjugating enzyme activity, and Formation of Incision Complex in GG-NER

5 of 77

2.28

3.54

7.40e-08

CL:3127

Protein localization to vacuolar membrane, and Ubiquitin conserved site

2 of 5

3.06

1.76

0.00065

CL:3113

IRAK2 mediated activation of TAK1 complex, and Cell population proliferation

2 of 5

3.06

1.76

0.00065

CL:629

Small GTPase mediated signal transduction, and Pleckstrin homology domain

2 of 43

2.13

0.85

0.0259

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04120

Ubiquitin mediated proteolysis

6 of 262

1.82

3.1

2.22e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9646399

Aggrephagy

2 of 24

2.38

0.81

0.0334

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031372

UBC13-MMS2 complex

2 of 3

3.29

1.64

0.0011

GOCC:0030496

Midbody

2 of 6

2.99

1.55

0.0016

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000608

Ubiquitin-conjugating enzyme E2

3 of 24

2.56

1.91

0.00030

IPR016135

Ubiquitin-conjugating enzyme/RWD-like

3 of 31

2.45

1.88

0.00031

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00212

Ubiquitin-conjugating enzyme E2, catalytic domain homologues

3 of 24

2.56

2.42

3.10e-05

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