A0A267FCX7 protein (Macrostomum lignano) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

A0A267FCX7

Uncharacterized protein. (717 aa)

Predicted Functional Partners:

A0A267DDL4

0.651

A0A267FJT5

0.651

A0A267G9D5

0.651

A0A267GG16

0.651

A0A267E428

0.632

A0A267GUQ5

0.632

A0A267E886

0.625

A0A267FBM2

0.625

A0A267DT70

0.579

A0A267EM24

0.579

Your Current Organism:

Macrostomum lignano

NCBI taxonomy Id: 282301
Other names: M. lignano

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A267DDL4	A0A267FCX7	Integrin beta.	Uncharacterized protein.	0.651
A0A267DT70	A0A267E428	TFIID_20kDa domain-containing protein.	Uncharacterized protein.	0.990
A0A267DT70	A0A267FCX7	TFIID_20kDa domain-containing protein.	Uncharacterized protein.	0.579
A0A267DT70	A0A267GUQ5	TFIID_20kDa domain-containing protein.	Uncharacterized protein.	0.990
A0A267E428	A0A267DT70	Uncharacterized protein.	TFIID_20kDa domain-containing protein.	0.990
A0A267E428	A0A267EM24	Uncharacterized protein.	TFIID_20kDa domain-containing protein.	0.990
A0A267E428	A0A267FCX7	Uncharacterized protein.	Uncharacterized protein.	0.632
A0A267E886	A0A267FBM2	Uncharacterized protein.	Uncharacterized protein.	0.916
A0A267E886	A0A267FCX7	Uncharacterized protein.	Uncharacterized protein.	0.625
A0A267EM24	A0A267E428	TFIID_20kDa domain-containing protein.	Uncharacterized protein.	0.990
A0A267EM24	A0A267FCX7	TFIID_20kDa domain-containing protein.	Uncharacterized protein.	0.579
A0A267EM24	A0A267GUQ5	TFIID_20kDa domain-containing protein.	Uncharacterized protein.	0.990
A0A267FBM2	A0A267E886	Uncharacterized protein.	Uncharacterized protein.	0.916
A0A267FBM2	A0A267FCX7	Uncharacterized protein.	Uncharacterized protein.	0.625
A0A267FCX7	A0A267DDL4	Uncharacterized protein.	Integrin beta.	0.651
A0A267FCX7	A0A267DT70	Uncharacterized protein.	TFIID_20kDa domain-containing protein.	0.579
A0A267FCX7	A0A267E428	Uncharacterized protein.	Uncharacterized protein.	0.632
A0A267FCX7	A0A267E886	Uncharacterized protein.	Uncharacterized protein.	0.625
A0A267FCX7	A0A267EM24	Uncharacterized protein.	TFIID_20kDa domain-containing protein.	0.579
A0A267FCX7	A0A267FBM2	Uncharacterized protein.	Uncharacterized protein.	0.625

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.895

expected number of edges:

10

PPI enrichment p-value:

0.0181

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006091

Generation of precursor metabolites and energy

10 of 226

1.26

1.91

1.62e-09

GO:0045333

Cellular respiration

5 of 87

1.38

1.25

0.00058

GO:0044237

Cellular metabolic process

11 of 1805

0.4

0.31

0.0105

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0020037

Heme binding

7 of 76

1.58

2.49

6.32e-08

GO:0009055

Electron transfer activity

8 of 116

1.46

2.26

2.90e-08

GO:0004129

Cytochrome-c oxidase activity

3 of 14

1.95

1.49

0.0011

GO:0016491

Oxidoreductase activity

9 of 553

0.83

0.78

5.31e-05

GO:0046872

Metal ion binding

8 of 652

0.71

0.55

0.0023

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3601

Mixed, incl. Cytochrome c7-like, and 4Fe-4S dicluster domain

6 of 6

2.62

5.69

8.33e-12

CL:3435

Oxidative phosphorylation, and Cytochrome c-like domain superfamily

10 of 107

1.59

3.34

8.65e-13

CL:3436

Oxidative phosphorylation, and Methane metabolism

8 of 90

1.57

2.83

6.45e-10

CL:3620

Respiratory chain, and 4Fe-4S dicluster domain

2 of 5

2.22

1.03

0.0122

CL:3469

Copper centre Cu(A), and HI0933-like protein

2 of 5

2.22

1.03

0.0122

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

6 of 100

1.4

1.71

7.30e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070469

Respirasome

7 of 66

1.64

2.73

2.02e-08

GOCC:0045278

Plasma membrane respiratory chain complex IV

2 of 2

2.62

1.25

0.0052

GOCC:0016020

Membrane

8 of 903

0.57

0.38

0.0182

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0349

Heme

6 of 64

1.59

2.22

1.06e-06

KW-0679

Respiratory chain

2 of 7

2.07

1.03

0.0112

KW-1133

Transmembrane helix

8 of 914

0.56

0.39

0.0115

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00116

Cytochrome C oxidase subunit II, periplasmic domain

2 of 3

2.44

0.87

0.0260

PF00034

Cytochrome c

3 of 26

1.68

0.8

0.0260

PF00115

Cytochrome C and Quinol oxidase polypeptide I

2 of 6

2.14

0.79

0.0347

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR009056

Cytochrome c-like domain

4 of 36

1.66

1.2

0.0029

IPR036909

Cytochrome c-like domain superfamily

4 of 40

1.62

1.18

0.0029

IPR045187

Cytochrome c/quinol oxidase subunit II

2 of 3

2.44

0.82

0.0319

IPR036257

Cytochrome C oxidase subunit II, transmembrane domain superfamily

2 of 3

2.44

0.82

0.0319

IPR023615

Cytochrome c oxidase, subunit I, copper-binding site

2 of 4

2.32

0.82

0.0319

(more ...)

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