A0A267FGG1 protein (Macrostomum lignano) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

A0A267FGG1

BED-type domain-containing protein. (869 aa)

Predicted Functional Partners:

A0A1I8GF19

0.500

A0A267DW48

0.500

A0A267FJK3

0.500

A0A267FWT1

0.500

A0A267GC39

0.500

A0A267E467

0.487

A0A267FJ37

0.487

A0A267G117

0.487

A0A267EJL6

0.417

A0A267GRQ8

0.417

Your Current Organism:

Macrostomum lignano

NCBI taxonomy Id: 282301
Other names: M. lignano

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1I8GF19	A0A267EJL6	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Protein kinase domain-containing protein.	0.461
A0A1I8GF19	A0A267FGG1	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	BED-type domain-containing protein.	0.500
A0A1I8GF19	A0A267GRQ8	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Protein kinase domain-containing protein.	0.461
A0A267DW48	A0A267EJL6	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Protein kinase domain-containing protein.	0.461
A0A267DW48	A0A267FGG1	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	BED-type domain-containing protein.	0.500
A0A267DW48	A0A267GRQ8	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Protein kinase domain-containing protein.	0.461
A0A267E467	A0A267FGG1	Uncharacterized protein.	BED-type domain-containing protein.	0.487
A0A267E467	A0A267FJ37	Uncharacterized protein.	Uncharacterized protein.	0.933
A0A267E467	A0A267G117	Uncharacterized protein.	Uncharacterized protein.	0.933
A0A267EJL6	A0A1I8GF19	Protein kinase domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.461
A0A267EJL6	A0A267DW48	Protein kinase domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.461
A0A267EJL6	A0A267FGG1	Protein kinase domain-containing protein.	BED-type domain-containing protein.	0.417
A0A267EJL6	A0A267FJK3	Protein kinase domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.461
A0A267EJL6	A0A267FWT1	Protein kinase domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.461
A0A267EJL6	A0A267GC39	Protein kinase domain-containing protein.	Uncharacterized protein.	0.461
A0A267FGG1	A0A1I8GF19	BED-type domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.500
A0A267FGG1	A0A267DW48	BED-type domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.500
A0A267FGG1	A0A267E467	BED-type domain-containing protein.	Uncharacterized protein.	0.487
A0A267FGG1	A0A267EJL6	BED-type domain-containing protein.	Protein kinase domain-containing protein.	0.417
A0A267FGG1	A0A267FJ37	BED-type domain-containing protein.	Uncharacterized protein.	0.487

page 1 of 3

Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006614

SRP-dependent cotranslational protein targeting to membrane

7 of 11

2.81

7.56

2.89e-15

GO:0045047

Protein targeting to ER

8 of 27

2.48

7.05

2.29e-15

GO:0006616

SRP-dependent cotranslational protein targeting to membrane, translocation

2 of 4

2.71

1.51

0.0018

GO:0000027

Ribosomal large subunit assembly

2 of 20

2.01

0.84

0.0256

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008312

7S RNA binding

5 of 6

2.93

5.18

2.33e-10

GO:0005047

Signal recognition particle binding

3 of 3

3.01

2.72

1.12e-05

GO:0043021

Ribonucleoprotein complex binding

4 of 45

1.95

2.06

5.56e-05

GO:0005048

Signal sequence binding

3 of 18

2.23

1.84

0.00030

GO:0030942

Endoplasmic reticulum signal peptide binding

2 of 3

2.83

1.51

0.0018

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005786

Signal recognition particle, endoplasmic reticulum targeting

5 of 6

2.93

5.33

1.22e-10

GO:0030867

Rough endoplasmic reticulum membrane

3 of 10

2.48

2.38

3.37e-05

GO:0005785

Signal recognition particle receptor complex

2 of 2

3.01

1.77

0.00063

GO:1990904

Ribonucleoprotein complex

8 of 444

1.26

1.68

2.79e-07

GO:0140534

Endoplasmic reticulum protein-containing complex

3 of 71

1.63

1.11

0.0046

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7281

7S RNA binding

5 of 6

2.93

5.14

2.86e-10

CL:6958

Cap-dependent Translation Initiation, and Translation elongation factor activity

8 of 169

1.68

3.17

5.23e-10

CL:7323

Organellar large ribosomal subunit, and Ribosomal protein S9

3 of 26

2.07

1.43

0.0017

CL:7325

Organellar large ribosomal subunit, and Ribosomal protein S9

2 of 21

1.98

0.75

0.0389

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03060

Protein export

8 of 35

2.37

6.99

6.07e-16

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1799339

SRP-dependent cotranslational protein targeting to membrane

10 of 127

1.9

5.23

5.67e-16

MAP-72766

Translation

11 of 272

1.61

3.8

1.07e-15

MAP-392499

Metabolism of proteins

11 of 987

1.05

1.39

8.65e-10

MAP-381070

IRE1alpha activates chaperones

2 of 18

2.05

0.76

0.0390

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0048500

Signal recognition particle

5 of 17

2.47

4.14

8.24e-09

GOCC:0005786

Signal recognition particle, endoplasmic reticulum targeting

4 of 16

2.4

3.15

8.06e-07

GOCC:0030867

Rough endoplasmic reticulum membrane

3 of 14

2.34

2.12

9.47e-05

GOCC:1990904

Ribonucleoprotein complex

8 of 438

1.27

1.67

4.46e-07

GOCC:0005785

Signal recognition particle receptor complex

2 of 6

2.53

1.37

0.0030

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0733

Signal recognition particle

3 of 3

3.01

3.0

3.44e-06

KW-0963

Cytoplasm

3 of 151

1.3

0.67

0.0316

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR042101

Signal recognition particle SRP54, N-terminal domain superfamily

2 of 2

3.01

1.01

0.0154

IPR036225

SRP/SRP receptor, N-terminal

2 of 2

3.01

1.01

0.0154

IPR013822

Signal recognition particle SRP54, helical bundle

2 of 2

3.01

1.01

0.0154

IPR000897

Signal recognition particle, SRP54 subunit, GTPase domain

2 of 3

2.83

1.0

0.0154

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00963

SRP54-type protein, helical bundle domain

2 of 2

3.01

1.52

0.0018

SM00962

SRP54-type protein, GTPase domain

2 of 2

3.01

1.52

0.0018

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