A0A267FP40 protein (Macrostomum lignano) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

A0A267FP40

Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (813 aa)

Predicted Functional Partners:

A0A267EMJ7

0.992

A0A267EPZ2

0.992

A0A267EJW3

0.961

A0A267H8S9

0.961

A0A267EAE9

0.903

A0A267EH89

0.903

A0A267F413

0.903

A0A267E886

0.872

A0A267FBM2

0.872

A0A1I8HDF6

0.857

Your Current Organism:

Macrostomum lignano

NCBI taxonomy Id: 282301
Other names: M. lignano

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1I8HDF6	A0A267EAE9	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.407
A0A1I8HDF6	A0A267EH89	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.407
A0A1I8HDF6	A0A267EJW3	TPR_REGION domain-containing protein.	Protein kinase domain-containing protein.	0.521
A0A1I8HDF6	A0A267EMJ7	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.625
A0A1I8HDF6	A0A267EPZ2	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.625
A0A1I8HDF6	A0A267F413	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.407
A0A1I8HDF6	A0A267FP40	TPR_REGION domain-containing protein.	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.857
A0A1I8HDF6	A0A267H8S9	TPR_REGION domain-containing protein.	Protein kinase domain-containing protein.	0.521
A0A267E886	A0A267EAE9	Uncharacterized protein.	Uncharacterized protein.	0.816
A0A267E886	A0A267EH89	Uncharacterized protein.	Uncharacterized protein.	0.816
A0A267E886	A0A267F413	Uncharacterized protein.	Uncharacterized protein.	0.816
A0A267E886	A0A267FBM2	Uncharacterized protein.	Uncharacterized protein.	0.916
A0A267E886	A0A267FP40	Uncharacterized protein.	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.872
A0A267EAE9	A0A1I8HDF6	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.407
A0A267EAE9	A0A267E886	Uncharacterized protein.	Uncharacterized protein.	0.816
A0A267EAE9	A0A267EH89	Uncharacterized protein.	Uncharacterized protein.	0.987
A0A267EAE9	A0A267EJW3	Uncharacterized protein.	Protein kinase domain-containing protein.	0.529
A0A267EAE9	A0A267EMJ7	Uncharacterized protein.	Uncharacterized protein.	0.540
A0A267EAE9	A0A267EPZ2	Uncharacterized protein.	Uncharacterized protein.	0.540
A0A267EAE9	A0A267F413	Uncharacterized protein.	Uncharacterized protein.	0.988

page 1 of 5

Network Stats

number of nodes:

4

number of edges:

3

average node degree:

1.5

avg. local clustering coefficient:

0.75

expected number of edges:

3

PPI enrichment p-value:

0.562

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1903778

Protein localization to vacuolar membrane

2 of 3

3.29

1.64

0.0011

GO:0010994

Free ubiquitin chain polymerization

2 of 4

3.16

1.64

0.0011

GO:0008283

Cell population proliferation

2 of 4

3.16

1.64

0.0011

GO:0070534

Protein K63-linked ubiquitination

2 of 6

2.99

1.63

0.0011

GO:2001234

Negative regulation of apoptotic signaling pathway

2 of 8

2.86

1.61

0.0012

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061631

Ubiquitin conjugating enzyme activity

4 of 24

2.68

3.52

2.61e-07

GO:0004842

Ubiquitin-protein transferase activity

5 of 177

1.91

2.64

1.43e-06

GO:0004869

Cysteine-type endopeptidase inhibitor activity

2 of 4

3.16

1.81

0.00054

GO:0140096

Catalytic activity, acting on a protein

6 of 1625

1.03

0.83

0.0018

GO:0016740

Transferase activity

6 of 1899

0.96

0.74

0.0031

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031371

Ubiquitin conjugating enzyme complex

2 of 5

3.06

1.53

0.0017

GO:0005819

Spindle

3 of 73

2.08

1.44

0.0017

GO:0000922

Spindle pole

2 of 14

2.62

1.34

0.0035

GO:0030496

Midbody

2 of 26

2.35

1.13

0.0083

GO:0005802

trans-Golgi network

2 of 28

2.32

1.12

0.0083

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3111

IRAK2 mediated activation of TAK1 complex, and Ubiquitin conjugating enzyme activity

4 of 14

2.92

3.87

7.40e-08

CL:3091

Mixed, incl. Ubiquitin conjugating enzyme activity, and Formation of Incision Complex in GG-NER

5 of 77

2.28

3.54

7.40e-08

CL:3127

Protein localization to vacuolar membrane, and Ubiquitin conserved site

2 of 5

3.06

1.76

0.00065

CL:3113

IRAK2 mediated activation of TAK1 complex, and Cell population proliferation

2 of 5

3.06

1.76

0.00065

CL:629

Small GTPase mediated signal transduction, and Pleckstrin homology domain

2 of 43

2.13

0.85

0.0259

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04120

Ubiquitin mediated proteolysis

6 of 262

1.82

3.1

2.22e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9646399

Aggrephagy

2 of 24

2.38

0.81

0.0334

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031372

UBC13-MMS2 complex

2 of 3

3.29

1.64

0.0011

GOCC:0030496

Midbody

2 of 6

2.99

1.55

0.0016

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000608

Ubiquitin-conjugating enzyme E2

3 of 24

2.56

1.91

0.00030

IPR016135

Ubiquitin-conjugating enzyme/RWD-like

3 of 31

2.45

1.88

0.00031

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00212

Ubiquitin-conjugating enzyme E2, catalytic domain homologues

3 of 24

2.56

2.42

3.10e-05

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