A0A267GMS5 protein (Macrostomum lignano) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

A0A267GMS5

Uncharacterized protein. (158 aa)

Predicted Functional Partners:

A0A267GU71

0.987

A0A267GU77

0.987

A0A267DJP9

0.986

A0A267DMS0

0.986

A0A267F1Q9

0.986

A0A267FI10

0.986

A0A267FIN2

0.986

A0A267H6A0

0.986

A0A267DBD3

0.984

A0A267DDU5

0.984

Your Current Organism:

Macrostomum lignano

NCBI taxonomy Id: 282301
Other names: M. lignano

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A267DBD3	A0A267DDU5	Uncharacterized protein.	ING domain-containing protein.	0.757
A0A267DBD3	A0A267F1Q9	Uncharacterized protein.	Uncharacterized protein.	0.974
A0A267DBD3	A0A267FIN2	Uncharacterized protein.	Uncharacterized protein.	0.974
A0A267DBD3	A0A267GMS5	Uncharacterized protein.	Uncharacterized protein.	0.984
A0A267DBD3	A0A267GU71	Uncharacterized protein.	Uncharacterized protein.	0.737
A0A267DBD3	A0A267GU77	Uncharacterized protein.	Uncharacterized protein.	0.737
A0A267DBD3	A0A267H6A0	Uncharacterized protein.	Uncharacterized protein.	0.974
A0A267DDU5	A0A267DBD3	ING domain-containing protein.	Uncharacterized protein.	0.757
A0A267DDU5	A0A267DJP9	ING domain-containing protein.	Uncharacterized protein.	0.757
A0A267DDU5	A0A267DMS0	ING domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.757
A0A267DDU5	A0A267F1Q9	ING domain-containing protein.	Uncharacterized protein.	0.755
A0A267DDU5	A0A267FI10	ING domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.757
A0A267DDU5	A0A267FIN2	ING domain-containing protein.	Uncharacterized protein.	0.755
A0A267DDU5	A0A267GMS5	ING domain-containing protein.	Uncharacterized protein.	0.984
A0A267DDU5	A0A267GU71	ING domain-containing protein.	Uncharacterized protein.	0.738
A0A267DDU5	A0A267GU77	ING domain-containing protein.	Uncharacterized protein.	0.738
A0A267DDU5	A0A267H6A0	ING domain-containing protein.	Uncharacterized protein.	0.755
A0A267DJP9	A0A267DDU5	Uncharacterized protein.	ING domain-containing protein.	0.757
A0A267DJP9	A0A267F1Q9	Uncharacterized protein.	Uncharacterized protein.	0.984
A0A267DJP9	A0A267FIN2	Uncharacterized protein.	Uncharacterized protein.	0.984

page 1 of 5

Network Stats

number of nodes:

9

number of edges:

23

average node degree:

5.11

avg. local clustering coefficient:

0.889

expected number of edges:

8

PPI enrichment p-value:

1.25e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006449

Regulation of translational termination

2 of 3

3.14

1.38

0.0033

GO:0016973

poly(A)+ mRNA export from nucleus

2 of 6

2.84

1.37

0.0033

GO:0006446

Regulation of translational initiation

2 of 6

2.84

1.37

0.0033

GO:0050658

RNA transport

3 of 44

2.15

1.31

0.0033

GO:0006913

Nucleocytoplasmic transport

3 of 109

1.76

1.21

0.0033

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005198

Structural molecule activity

6 of 195

1.81

2.77

2.33e-07

GO:0003735

Structural constituent of ribosome

4 of 125

1.83

1.76

0.00019

GO:0000822

Inositol hexakisphosphate binding

2 of 3

3.14

1.69

0.00088

GO:0031369

Translation initiation factor binding

2 of 10

2.62

1.29

0.0044

GO:0005543

Phospholipid binding

2 of 41

2.01

0.75

0.0395

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005643

Nuclear pore

3 of 21

2.48

2.14

0.00010

GO:0044614

Nuclear pore cytoplasmic filaments

2 of 2

3.32

2.05

0.00020

GO:0005840

Ribosome

4 of 136

1.79

1.8

0.00013

GO:0044391

Ribosomal subunit

3 of 91

1.84

1.42

0.0013

GO:0022627

Cytosolic small ribosomal subunit

2 of 19

2.34

1.3

0.0039

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7298

Formation of the ternary complex, and subsequently, the 43S complex

4 of 24

2.54

3.15

1.10e-06

CL:6165

Mixed, incl. LCCL domain, and CalX-like domain superfamily

2 of 12

2.54

1.46

0.0021

CL:8956

Nuclear pore

2 of 13

2.51

1.43

0.0023

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

4 of 157

1.73

1.79

9.92e-05

map03013

RNA transport

3 of 196

1.51

0.99

0.0068

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72695

Formation of the ternary complex, and subsequently, the 43S complex

4 of 53

2.2

2.58

7.71e-06

MAP-72702

Ribosomal scanning and start codon recognition

4 of 56

2.17

2.57

7.71e-06

MAP-72706

GTP hydrolysis and joining of the 60S ribosomal subunit

4 of 79

2.03

2.4

1.07e-05

MAP-72689

Formation of a pool of free 40S subunits

4 of 90

1.97

2.31

1.42e-05

MAP-1799339

SRP-dependent cotranslational protein targeting to membrane

4 of 91

1.96

2.31

1.42e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005643

Nuclear pore

3 of 24

2.42

2.0

0.00018

GOCC:0022627

Cytosolic small ribosomal subunit

2 of 13

2.51

1.39

0.0028

GOCC:0032991

Protein-containing complex

7 of 1843

0.9

0.74

0.0013

GOCC:0005634

Nucleus

4 of 892

0.97

0.55

0.0309

GOCC:0043226

Organelle

9 of 4415

0.63

0.48

0.0025

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

3 of 57

2.04

1.64

0.00060

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